1 00:00:13,060 --> 00:00:15,831 Sanchez: [ Breathing heavily ] Five... 2 00:00:15,832 --> 00:00:18,235 six... 3 00:00:18,236 --> 00:00:19,806 seven... 4 00:00:19,807 --> 00:00:22,177 eight. 5 00:00:22,178 --> 00:00:37,842 ♪ 6 00:00:37,843 --> 00:00:40,079 Two... 7 00:00:40,080 --> 00:00:42,518 three. 8 00:00:42,519 --> 00:00:50,433 ♪ 9 00:00:50,434 --> 00:00:54,174 The earliest memory I have as weight being a thing for me 10 00:00:54,175 --> 00:00:58,349 was being taken by my mom to a class on Saturdays 11 00:00:58,350 --> 00:00:59,719 that was basically, like, 12 00:00:59,720 --> 00:01:03,226 a weight-management class for kids. 13 00:01:07,134 --> 00:01:09,204 And I was probably 8 or 9. 14 00:01:13,146 --> 00:01:15,283 Luxmore: Taking up space is definitely something 15 00:01:15,284 --> 00:01:19,157 that has been on my mind, like, my whole life, 16 00:01:19,158 --> 00:01:22,765 just because my size has significantly affected 17 00:01:22,766 --> 00:01:24,736 every aspect of my life. 18 00:01:24,737 --> 00:01:27,174 I was the big kid, definitely. 19 00:01:29,311 --> 00:01:31,916 Arrellin: I was little-- was a little girl, 20 00:01:31,917 --> 00:01:34,555 and then I started to, like, gain weight. 21 00:01:34,556 --> 00:01:37,661 Something was obviously wrong. 22 00:01:37,662 --> 00:01:39,632 Sanchez: When I first heard of GLP-1s, 23 00:01:39,633 --> 00:01:41,770 it sounded like this thing in Hollywood 24 00:01:41,771 --> 00:01:43,507 that all the celebrities were using. 25 00:01:43,508 --> 00:01:45,143 - ...Kelly Clarkson... - ...Whoopi Goldberg... 26 00:01:45,144 --> 00:01:46,880 Reporter: Television icon Oprah Winfrey 27 00:01:46,881 --> 00:01:49,686 revealing she's using medication for weight loss. 28 00:01:49,687 --> 00:01:51,556 Sanchez: I started hearing from other women, 29 00:01:51,557 --> 00:01:55,296 and the success they were having was pretty significant. 30 00:01:55,297 --> 00:01:58,904 In the first couple weeks, I was losing weight immediately. 31 00:01:58,905 --> 00:02:01,208 Luxmore: All of the extreme distress 32 00:02:01,209 --> 00:02:04,214 that I had been feeling with just instantly gone. 33 00:02:05,785 --> 00:02:08,189 [ Sighs ] 34 00:02:08,190 --> 00:02:10,728 [ Voice breaking ] It is such an incredible sense of relief. 35 00:02:11,664 --> 00:02:14,401 Arrellin: My doctor is trying everything she can 36 00:02:14,402 --> 00:02:16,573 to make it better for me. 37 00:02:16,574 --> 00:02:19,946 I want to lose weight more than anything on Earth, I swear. 38 00:02:19,947 --> 00:02:23,887 This is unquestionably a medical innovation. 39 00:02:23,888 --> 00:02:25,624 Reporter #2: Weight loss is something 40 00:02:25,625 --> 00:02:27,595 that Americans have been chasing for decades. 41 00:02:27,596 --> 00:02:30,199 There's a new class of drugs that could be a game changer. 42 00:02:30,200 --> 00:02:32,404 Allen: This is not just a pharmaceutical drug. 43 00:02:32,405 --> 00:02:34,842 This is a cultural shift that we're seeing. 44 00:02:34,843 --> 00:02:37,681 - I lost eight pounds. - What are you eating? Muffins? 45 00:02:37,682 --> 00:02:39,451 Strudels? Put it down and let me talk to you for a second. 46 00:02:39,452 --> 00:02:41,422 Winfrey: Whether you have $10 or $10 million, 47 00:02:41,423 --> 00:02:43,593 a fat butt is a fat butt. 48 00:02:43,594 --> 00:02:46,733 Diet culture set the stage for these drugs. 49 00:02:46,734 --> 00:02:48,904 I was, like, the unhealthiest I've been in my entire life, 50 00:02:48,905 --> 00:02:50,707 but I was also the thinnest. 51 00:02:50,708 --> 00:02:53,212 Gay: People treat thinness as a virtue. 52 00:02:53,213 --> 00:02:55,383 It's practically biblical for a lot of people. 53 00:02:55,384 --> 00:02:57,487 I wouldn't recommend anybody be fat in this world. 54 00:02:57,488 --> 00:02:59,659 It is so traumatizing. 55 00:02:59,660 --> 00:03:01,663 I have a fear of fat people on planes. 56 00:03:01,664 --> 00:03:03,900 What are you scared of? Them being near me. 57 00:03:03,901 --> 00:03:06,271 Woman: They're in a shortage. 58 00:03:06,272 --> 00:03:07,741 They can't make enough to actually meet the demand. 59 00:03:07,742 --> 00:03:09,512 Tovar: The path we're on right now, 60 00:03:09,513 --> 00:03:11,983 the path where we don't reckon with our attitudes 61 00:03:11,984 --> 00:03:13,687 about higher-weight people... 62 00:03:13,688 --> 00:03:15,389 Reporter #3: ...drug market could eventually 63 00:03:15,390 --> 00:03:18,563 hit $100 billion in sales a year. 64 00:03:18,564 --> 00:03:20,333 ...is a path of destruction. 65 00:03:20,334 --> 00:03:27,480 ♪ 66 00:03:27,481 --> 00:03:29,384 Interviewer: You look very unhappy in that picture. 67 00:03:29,385 --> 00:03:31,388 I thought fat men were supposed to be jolly. 68 00:03:31,389 --> 00:03:33,025 What did she model, car covers? 69 00:03:33,026 --> 00:03:34,629 I'm really gonna have to go on a crash diet. 70 00:03:34,630 --> 00:03:36,900 Some girl ate Monica! 71 00:03:36,901 --> 00:03:38,804 Stern: I don't think you're aware that you're a heavyset woman. 72 00:03:38,805 --> 00:03:40,574 - ...trying to lose weight. - What's with the gut? 73 00:03:40,575 --> 00:03:42,912 - Lay off me! I'm starving! - There you go. 74 00:03:42,913 --> 00:03:44,549 Beautiful. 75 00:03:47,822 --> 00:03:49,457 We're gonna start with some deep breaths. 76 00:03:49,458 --> 00:03:51,529 Blum: Over the years, we have treated obesity 77 00:03:51,530 --> 00:03:53,332 as this problem to fix. 78 00:03:53,333 --> 00:03:55,403 Simmons: Next 45 minutes is your time. 79 00:03:55,404 --> 00:03:57,307 Blum: There have been diets, there have been drugs 80 00:03:57,308 --> 00:03:59,512 that hit the market that seemed promising. 81 00:03:59,513 --> 00:04:02,718 Man: Keep away from salt, white flour, white sugar... 82 00:04:02,719 --> 00:04:04,822 Blum: But throughout all of this, 83 00:04:04,823 --> 00:04:06,960 obesity rates have continued to climb. 84 00:04:06,961 --> 00:04:09,732 We know that obesity is linked to a range 85 00:04:09,733 --> 00:04:12,003 of pretty devastating conditions. 86 00:04:12,004 --> 00:04:14,341 Man #2: Americans will do almost anything to lose weight. 87 00:04:14,342 --> 00:04:16,713 Blum: But also, our entire culture 88 00:04:16,714 --> 00:04:18,984 incentivizes weight loss. Woman: Obsession. 89 00:04:18,985 --> 00:04:21,956 Blum: So while I think there's a lot of excitement around GLP-1s 90 00:04:21,957 --> 00:04:23,860 and there's reason to be excited, 91 00:04:23,861 --> 00:04:26,365 there's also reason to look at history 92 00:04:26,366 --> 00:04:28,503 and just be careful and approach these drugs 93 00:04:28,504 --> 00:04:30,006 seriously and with caution. 94 00:04:30,007 --> 00:04:32,979 ♪ 95 00:04:35,050 --> 00:04:37,822 [ Child speaking in background ] 96 00:04:38,924 --> 00:04:40,594 Sanchez: If you look at photos of me... 97 00:04:43,567 --> 00:04:45,637 ...as far as I recall, 98 00:04:45,638 --> 00:04:47,541 I was not an overweight child. 99 00:04:47,542 --> 00:04:50,079 ♪ Get in shape, girl ♪ 100 00:04:50,080 --> 00:04:53,520 ♪ You got the feeling ♪ 101 00:04:53,521 --> 00:04:55,423 ♪ Get in shape, girl ♪ 102 00:04:55,424 --> 00:04:58,697 According to the growth chart from my pediatrician, 103 00:04:58,698 --> 00:05:01,936 I must have been in the higher numbers. 104 00:05:01,937 --> 00:05:05,844 My mom definitely had body-image issues, 105 00:05:05,845 --> 00:05:08,917 and I think hearing from the pediatrician 106 00:05:08,918 --> 00:05:11,756 that maybe I was on a higher end of the growth chart 107 00:05:11,757 --> 00:05:13,960 triggered something in her, 108 00:05:13,961 --> 00:05:16,599 and she then projected it on me 109 00:05:16,600 --> 00:05:21,509 and was always trying to fix me. 110 00:05:21,510 --> 00:05:24,916 And unfortunately, that trailed into teenage years, 111 00:05:24,917 --> 00:05:26,653 young adulthood. 112 00:05:26,654 --> 00:05:30,493 Binge eating created almost a coping mechanism 113 00:05:30,494 --> 00:05:34,535 that I would use in high-anxiety situations. 114 00:05:34,536 --> 00:05:38,142 At my 18th birthday, 115 00:05:38,143 --> 00:05:41,950 I opened a gift from my parents, and when I opened the box, 116 00:05:41,951 --> 00:05:44,956 it was an image of my personal trainer 117 00:05:44,957 --> 00:05:47,828 that I was being gifted and workout clothes. 118 00:05:47,829 --> 00:05:50,701 And that was from her. [ Chuckles ] 119 00:05:51,803 --> 00:05:53,607 And that's a core memory. 120 00:05:53,608 --> 00:05:57,681 And push, and push out and in. 121 00:05:57,682 --> 00:05:59,852 All right, kick swings right here. 122 00:05:59,853 --> 00:06:03,560 Up, two. Okay, tap it, tap it... 123 00:06:03,561 --> 00:06:05,731 [ Clicking ] Oh, there you go. 124 00:06:05,732 --> 00:06:07,133 Ooh. 125 00:06:07,134 --> 00:06:09,104 You want to season it with some salt? 126 00:06:09,105 --> 00:06:12,010 Sanchez: I think the diet culture that entered our home 127 00:06:12,011 --> 00:06:15,784 created a very dangerous dynamic for me, 128 00:06:15,785 --> 00:06:19,090 already putting a complexity on the size I was. 129 00:06:19,091 --> 00:06:23,132 My weight hit a peak in my mid-20s. 130 00:06:23,133 --> 00:06:26,471 I needed help. 131 00:06:26,472 --> 00:06:29,578 What causes someone to be obese, um, 132 00:06:29,579 --> 00:06:31,716 is really complicated, right? 133 00:06:31,717 --> 00:06:35,156 So not only is it an interplay between environment and biology, 134 00:06:35,157 --> 00:06:37,795 genetics and individual choices, 135 00:06:37,796 --> 00:06:40,934 but it's also about societal expectations. 136 00:06:40,935 --> 00:06:44,074 Society tries in every way possible 137 00:06:44,075 --> 00:06:45,844 to make you feel like an outcast. 138 00:06:45,845 --> 00:06:48,516 As a fat person, you are just used to the way 139 00:06:48,517 --> 00:06:50,654 that society treats you, but you don't understand 140 00:06:50,655 --> 00:06:53,827 how badly you are treated until you lose weight. 141 00:06:53,828 --> 00:06:57,033 I think it's very easy to know something intellectually, 142 00:06:57,034 --> 00:06:59,905 to know I have every right to be in this world exactly as I am, 143 00:06:59,906 --> 00:07:02,010 but it's a lot harder to maintain that 144 00:07:02,011 --> 00:07:03,947 while you actually live in a world 145 00:07:03,948 --> 00:07:05,584 that is pretty inhospitable to fatness. 146 00:07:05,585 --> 00:07:07,020 Things I hate as a fat person-- 147 00:07:07,021 --> 00:07:10,961 concert seating because, oh, my God, 148 00:07:10,962 --> 00:07:13,265 this is, like, actively discriminatory. 149 00:07:13,266 --> 00:07:15,704 Gay: We know that many, many people in this country 150 00:07:15,705 --> 00:07:18,108 are fat, and yet there are very few stores 151 00:07:18,109 --> 00:07:22,851 that cater to fat people for clothing. 152 00:07:22,852 --> 00:07:25,590 Doctors refuse to treat you for what you actually 153 00:07:25,591 --> 00:07:28,028 are trying to see them for, like a sore throat 154 00:07:28,029 --> 00:07:31,502 or a cold or a broken ankle. 155 00:07:31,503 --> 00:07:34,074 They're always trying to address fatness. 156 00:07:34,075 --> 00:07:36,044 Everything looks good. 157 00:07:36,045 --> 00:07:38,182 We'll call you with your pap results when they come in. 158 00:07:38,183 --> 00:07:40,987 Okay. Thank you. 159 00:07:40,988 --> 00:07:44,862 And I'm sure Dr. Lishen has mentioned this to you before, 160 00:07:44,863 --> 00:07:47,701 but you should think about gastric bypass. 161 00:07:47,702 --> 00:07:50,974 Okay. Um... but we didn't do, like, 162 00:07:50,975 --> 00:07:53,913 any bloodwork or anything today. 163 00:07:53,914 --> 00:07:56,586 Isn't that something that maybe you should look at 164 00:07:56,587 --> 00:08:00,927 before you recommend a major surgery? 165 00:08:00,928 --> 00:08:04,100 I think there's so much hatred 166 00:08:04,101 --> 00:08:07,073 of weight gain and of larger-bodied people, 167 00:08:07,074 --> 00:08:09,945 and there's so much praise to be had 168 00:08:09,946 --> 00:08:13,920 for being seen as dieting and losing weight. 169 00:08:13,921 --> 00:08:17,293 I just know what it's like to sort of have that feeling 170 00:08:17,294 --> 00:08:19,598 that all eyes are on me, 171 00:08:19,599 --> 00:08:23,640 I'm losing money or work or respect because of my body, 172 00:08:23,641 --> 00:08:26,646 and I could make it all go away if I just... blank. 173 00:08:27,748 --> 00:08:30,754 You're so tall. Wow. 174 00:08:30,755 --> 00:08:32,891 Sanchez: I made the decision to have the drastic change 175 00:08:32,892 --> 00:08:35,764 of gastric bypass, 176 00:08:35,765 --> 00:08:38,870 and, really, the idea was sold to me that this will fix things. 177 00:08:38,871 --> 00:08:40,640 Dropped about 120 pounds. 178 00:08:40,641 --> 00:08:42,276 It really worked for me. 179 00:08:42,277 --> 00:08:45,182 I wish I had done it 10 years ago. 180 00:08:45,183 --> 00:08:47,086 Sanchez: And it was successful. 181 00:08:47,087 --> 00:08:50,126 I lost 110 pounds within that first year. 182 00:08:50,127 --> 00:08:51,796 I felt great. 183 00:08:51,797 --> 00:08:53,700 It gave me the opportunity 184 00:08:53,701 --> 00:08:56,138 to have beautiful wedding pictures 185 00:08:56,139 --> 00:08:58,710 and fit into a dress 186 00:08:58,711 --> 00:09:02,150 that I don't think I ever would have fit into before that. 187 00:09:02,151 --> 00:09:03,285 There you go. 188 00:09:03,286 --> 00:09:05,724 Even after losing 110 pounds, 189 00:09:05,725 --> 00:09:07,961 the portion of my body 190 00:09:07,962 --> 00:09:09,832 that wouldn't change drastically 191 00:09:09,833 --> 00:09:13,005 was my lower legs and my hips. 192 00:09:13,006 --> 00:09:16,679 And within the last year 193 00:09:16,680 --> 00:09:18,683 oddly enough, through a TikTok, 194 00:09:18,684 --> 00:09:20,854 I learned what lipedema was. 195 00:09:20,855 --> 00:09:22,958 Woman: Lipedema usually affects the legs. 196 00:09:22,959 --> 00:09:25,931 It can affect the arms, but usually it's the legs. 197 00:09:25,932 --> 00:09:28,703 Everyone with lipedema will present differently. 198 00:09:28,704 --> 00:09:30,172 Sanchez: I could sit there going, 199 00:09:30,173 --> 00:09:33,278 "That's exactly what my legs are." 200 00:09:33,279 --> 00:09:37,386 I wanted to talk a little more about what lipedema is. 201 00:09:37,387 --> 00:09:40,727 It's a genetic fat disorder, um, 202 00:09:40,728 --> 00:09:42,664 where you basically have 203 00:09:42,665 --> 00:09:46,004 a layer of diseased fat under your skin. 204 00:09:46,005 --> 00:09:48,041 It's not just in my head. 205 00:09:48,042 --> 00:09:51,816 It's not just me failing at trying to lose weight. 206 00:09:51,817 --> 00:09:54,688 The other thing is, I didn't know it was hereditary. 207 00:09:54,689 --> 00:09:58,128 It was something that was in my genes. 208 00:09:58,129 --> 00:10:02,036 I don't know what it feels like, at the end of the day, 209 00:10:02,037 --> 00:10:04,374 to not have heavy legs. 210 00:10:04,375 --> 00:10:07,246 And it would be nice to know. 211 00:10:07,247 --> 00:10:11,822 And the more research I did in my lipidema communities, 212 00:10:11,823 --> 00:10:16,832 I was hearing and seeing results from other women taking GLP-1s 213 00:10:16,833 --> 00:10:20,139 having reduction in their lipedema. 214 00:10:20,140 --> 00:10:22,176 And when I got on Mounjaro, and all those things suddenly 215 00:10:22,177 --> 00:10:24,682 started to, like, subside. 216 00:10:24,683 --> 00:10:27,019 Sanchez: So that helped me realize 217 00:10:27,020 --> 00:10:31,261 I need a better tool to help fix this. 218 00:10:31,262 --> 00:10:32,665 ♪ 219 00:10:38,409 --> 00:10:45,089 ♪ 220 00:10:45,090 --> 00:10:48,863 Luxmore: Thinking about weight is probably the number-one item 221 00:10:48,864 --> 00:10:52,236 that's on my mind most of the time. 222 00:10:52,237 --> 00:10:56,378 Like, I'm always comparing myself to everyone around me. 223 00:10:56,379 --> 00:10:58,917 I sized up this crew when they walked in 224 00:10:58,918 --> 00:11:00,720 and, like, the first thing is like, 225 00:11:00,721 --> 00:11:03,058 "Yep, I'm definitely bigger than all these people." 226 00:11:03,059 --> 00:11:05,429 Or it's like a game. Like, the game is, 227 00:11:05,430 --> 00:11:08,770 "Am I the biggest person in the room?" 228 00:11:08,771 --> 00:11:12,043 I have this negative internal narrative about my weight 229 00:11:12,044 --> 00:11:13,980 that's always been there. 230 00:11:13,981 --> 00:11:16,886 I don't know if my family, to this day, 231 00:11:16,887 --> 00:11:19,324 understands the implications of weight. 232 00:11:19,325 --> 00:11:21,762 We know, of course, 233 00:11:21,763 --> 00:11:24,467 that obesity is associated with a number of health risks. 234 00:11:24,468 --> 00:11:27,306 It just wasn't a topic. 235 00:11:27,307 --> 00:11:30,179 There are clear, undeniable instances 236 00:11:30,180 --> 00:11:34,153 where my weight has, like, caused a social interaction 237 00:11:34,154 --> 00:11:36,057 to go a certain way. 238 00:11:36,058 --> 00:11:37,961 Dating is a great example. 239 00:11:37,962 --> 00:11:40,800 Like, you know, there's really not any other way to do it 240 00:11:40,801 --> 00:11:42,771 where, like, you're chatting and then you're like, 241 00:11:42,772 --> 00:11:46,077 "Hey, let's send each other photos." 242 00:11:46,078 --> 00:11:49,918 And then that person drops off the face of the planet. 243 00:11:49,919 --> 00:11:52,423 I think that's a pretty clear indication, right? 244 00:11:54,962 --> 00:11:57,433 What I want is I want to look... 245 00:11:57,434 --> 00:12:00,774 it's such a loaded word, but I want to look "normal." 246 00:12:03,245 --> 00:12:06,384 The reality of a GLP-1 med becoming available 247 00:12:06,385 --> 00:12:08,956 was sometime in 2023, like, 248 00:12:08,957 --> 00:12:11,061 because these articles started popping up. 249 00:12:13,099 --> 00:12:16,204 The part that stood out to me was this concept of food noise. 250 00:12:16,205 --> 00:12:17,941 You're eating breakfast and you're thinking, 251 00:12:17,942 --> 00:12:20,479 "What am I gonna have for lunch?" 252 00:12:20,480 --> 00:12:23,953 When I read people saying the food noise just went away, 253 00:12:23,954 --> 00:12:28,128 I was like, "That's not possible." 254 00:12:28,129 --> 00:12:31,067 Okay, friends, it's dinner time. 255 00:12:31,068 --> 00:12:34,508 Give you a little preview of what's for dinner today. 256 00:12:34,509 --> 00:12:38,382 I have some of this vegetable mélange. 257 00:12:38,383 --> 00:12:40,219 I like saying that word. 258 00:12:40,220 --> 00:12:42,991 Dr. Rich: Hunger is a necessary 259 00:12:42,992 --> 00:12:46,231 biologic, um, impulse, 260 00:12:46,232 --> 00:12:47,534 so that you don't starve. 261 00:12:47,535 --> 00:12:52,209 And satiety, which says, "That's enough," 262 00:12:52,210 --> 00:12:55,482 is necessary so that you don't overeat. 263 00:12:55,483 --> 00:12:57,988 And everyone's been trying to find out 264 00:12:57,989 --> 00:13:00,259 what shuts on and off those signals. 265 00:13:00,260 --> 00:13:03,165 If we could either turn on satiety 266 00:13:03,166 --> 00:13:04,902 or shut off hunger, 267 00:13:04,903 --> 00:13:07,239 we can get people to lose weight. 268 00:13:07,240 --> 00:13:10,179 There's a brand-new drug that's just been FDA-approved 269 00:13:10,180 --> 00:13:13,553 called Byetta, which comes from the saliva 270 00:13:13,554 --> 00:13:15,155 of the Gila monster. 271 00:13:15,156 --> 00:13:17,159 It's actually synthetic lizard spit. 272 00:13:17,160 --> 00:13:19,030 - Oh, my goodness. - You're making this up. 273 00:13:19,031 --> 00:13:20,600 And so you inject it. and the beauty of it is, 274 00:13:20,601 --> 00:13:22,838 is that your diabetes gets better 275 00:13:22,839 --> 00:13:24,541 and you don't gain weight. 276 00:13:24,542 --> 00:13:28,583 Decades ago, we were looking at other diseases like diabetes. 277 00:13:28,584 --> 00:13:31,555 And that's where hormones such as GLP-1 278 00:13:31,556 --> 00:13:33,593 came into the picture. 279 00:13:33,594 --> 00:13:36,599 Some really smart researcher found out 280 00:13:36,600 --> 00:13:39,905 that the Gila monster only eats three to four times a year, 281 00:13:39,906 --> 00:13:42,042 and he found out that the spit of it 282 00:13:42,043 --> 00:13:45,583 is just like a hormone called GLP-1 in humans. 283 00:13:45,584 --> 00:13:48,623 These are hormones that help the body process sugar, 284 00:13:48,624 --> 00:13:51,094 and people were able to isolate them, 285 00:13:51,095 --> 00:13:53,933 to study them for treatment. 286 00:13:53,934 --> 00:13:56,037 Reporter: It will be used as a twice-a-day injection... 287 00:13:56,038 --> 00:13:57,473 And they're effective for diabetes, 288 00:13:57,474 --> 00:13:59,410 which is extremely exciting. 289 00:13:59,411 --> 00:14:02,149 But they also induce this very welcome side effect, 290 00:14:02,150 --> 00:14:04,187 which is weight loss. 291 00:14:04,188 --> 00:14:07,594 After two years on Byetta, patients lost 10 pounds. 292 00:14:07,595 --> 00:14:09,464 Blum: GLP-1s slow down the rate 293 00:14:09,465 --> 00:14:11,334 at which food leaves your stomach, 294 00:14:11,335 --> 00:14:14,975 so you basically are feeling fuller for much longer. 295 00:14:14,976 --> 00:14:16,645 What I find really fascinating 296 00:14:16,646 --> 00:14:19,585 is that the drugs also target the brain. 297 00:14:19,586 --> 00:14:23,358 Man: They help us not to want to eat the things we shouldn't. 298 00:14:23,359 --> 00:14:25,930 Dr. Rich: So then they started to scratch their head-- 299 00:14:25,931 --> 00:14:30,039 maybe this could be a weight-loss drug, as well. 300 00:14:30,875 --> 00:14:35,349 This is the once-weekly, single-use Zepbound pen. 301 00:14:35,350 --> 00:14:37,119 Announcer: Ask your doctor about once-weekly Mounjaro. 302 00:14:37,120 --> 00:14:40,125 People taking Wegovy lost an average of 35 pounds. 303 00:14:40,126 --> 00:14:43,465 ♪ Oh, oh, oh, oh, Ozempic ♪ 304 00:14:44,234 --> 00:14:46,639 There are two pharmaceutical companies right now 305 00:14:46,640 --> 00:14:48,275 that are the major players. 306 00:14:48,276 --> 00:14:51,114 Novo Nordisk makes Ozempic and Wegovy, 307 00:14:51,115 --> 00:14:54,387 and both of those medications contain semaglutide, 308 00:14:54,388 --> 00:14:57,393 which is sort of the active molecule in those drugs. 309 00:14:57,394 --> 00:14:59,531 The big rival is Eli Lilly, 310 00:14:59,532 --> 00:15:01,535 which makes Mounjaro for diabetes 311 00:15:01,536 --> 00:15:03,539 and Zepbound for weight loss. 312 00:15:03,540 --> 00:15:05,643 And those drugs contain a molecule 313 00:15:05,644 --> 00:15:08,215 that's called tirzepatide. 314 00:15:08,216 --> 00:15:11,221 I don't know that anyone expected 315 00:15:11,222 --> 00:15:13,124 quite the demand that we're seeing. 316 00:15:13,125 --> 00:15:15,295 This is unprecedented demand. 317 00:15:15,296 --> 00:15:18,001 [ Overlapping voices ] 318 00:15:18,002 --> 00:15:20,005 Day one of Ozempic. 319 00:15:20,006 --> 00:15:23,144 - Currently on week 23. - I got my Ozempic yesterday. 320 00:15:23,145 --> 00:15:25,415 Woman: Being on a GLP-1 has changed my life. 321 00:15:25,416 --> 00:15:28,689 I'm no longer obsessed with food 24/7. 322 00:15:28,690 --> 00:15:32,998 Recently lost 15 pounds due to Ozempic. 323 00:15:32,999 --> 00:15:35,703 I lost 2 more pounds this week, so I'm 243. 324 00:15:35,704 --> 00:15:37,641 Weight-loss drugs like Ozempic 325 00:15:37,642 --> 00:15:39,443 are incredibly popular right now. 326 00:15:39,444 --> 00:15:41,014 Fallon: You look great! 327 00:15:41,015 --> 00:15:42,249 How are you staying in shape these days? 328 00:15:42,250 --> 00:15:43,451 Well, that's Ozempic. 329 00:15:43,452 --> 00:15:45,557 Everybody looks so great. 330 00:15:45,558 --> 00:15:47,561 When I look around this room, I can't help but wonder, 331 00:15:47,562 --> 00:15:50,165 is Ozempic right for me? 332 00:15:50,166 --> 00:15:53,171 That all, of course, comes at a really expensive cost. 333 00:15:53,172 --> 00:15:56,444 Out of pocket, it will run you about $1,000 a month... 334 00:15:56,445 --> 00:15:58,583 Blum: These are really expensive medications. 335 00:15:58,584 --> 00:16:01,221 And in terms of actually getting insurance coverage, 336 00:16:01,222 --> 00:16:03,358 it's really a moving target 337 00:16:03,359 --> 00:16:06,464 'cause our entire medical system still views obesity 338 00:16:06,465 --> 00:16:09,470 as a vanity project if you're trying to lose weight. 339 00:16:09,471 --> 00:16:12,009 Reporter: Starting April 1, North Carolina will stop paying 340 00:16:12,010 --> 00:16:15,182 for obesity drug coverage in its state health plan 341 00:16:15,183 --> 00:16:18,556 as the costs soared to $100 million last year. 342 00:16:22,063 --> 00:16:24,333 Sanchez: My insurance didn't cover weight-loss meds. 343 00:16:24,334 --> 00:16:28,108 "Your prior authorization for Ozempic has been denied." 344 00:16:28,109 --> 00:16:30,580 I felt I needed to take it into my own hands, 345 00:16:30,581 --> 00:16:33,485 and if I can find it, I'm gonna buy it and use it, 346 00:16:33,486 --> 00:16:36,224 regardless of where it came from. 347 00:16:36,225 --> 00:16:39,363 It's led to these compounding pharmacies-- 348 00:16:39,364 --> 00:16:41,100 I don't know if you're familiar with the term. 349 00:16:41,101 --> 00:16:42,369 But compounding pharmacies 350 00:16:42,370 --> 00:16:44,073 are these pharmacies 351 00:16:44,074 --> 00:16:47,079 that are allowed to, quote, "manufacture" 352 00:16:47,080 --> 00:16:49,083 the drug in their pharmacy 353 00:16:49,084 --> 00:16:51,321 to do an end-around from your doctor 354 00:16:51,322 --> 00:16:53,091 and from your insurance company, 355 00:16:53,092 --> 00:16:54,460 so you can have this drug. 356 00:16:55,396 --> 00:16:58,134 Luxmore: I scheduled an appointment with my primary-care provider, 357 00:16:58,135 --> 00:17:01,374 and I said, "I think I want to try, uh, 358 00:17:01,375 --> 00:17:04,113 Eli Lilly's Zepbound. My insurance doesn't cover it." 359 00:17:04,114 --> 00:17:05,783 She just responded like, "Well, we'll need to do 360 00:17:05,784 --> 00:17:07,252 some tests and stuff." 361 00:17:07,253 --> 00:17:10,359 And I was like, "Ah, screw this." 362 00:17:10,360 --> 00:17:12,396 And a week later, 363 00:17:12,397 --> 00:17:15,503 the medication was at my house. 364 00:17:15,504 --> 00:17:17,373 The compounded medication that I used-- 365 00:17:17,374 --> 00:17:19,544 about $450 a month. 366 00:17:19,545 --> 00:17:22,416 I know that I'm very fortunate in having an income 367 00:17:22,417 --> 00:17:23,753 that can support that, 368 00:17:23,754 --> 00:17:26,224 and I know a lot of people can't. 369 00:17:28,162 --> 00:17:30,165 Sanchez: A friend of mine mentioned 370 00:17:30,166 --> 00:17:32,169 that she had learned about these peptides 371 00:17:32,170 --> 00:17:34,541 and work just the same at a less cost 372 00:17:34,542 --> 00:17:37,413 than paying out of pocket for the brand name, 373 00:17:37,414 --> 00:17:42,156 because it's in a wholesale type of environment. 374 00:17:42,157 --> 00:17:44,160 I said, "Why not?" 375 00:17:44,161 --> 00:17:45,395 The most money I would have lost out of pocket 376 00:17:45,396 --> 00:17:47,266 at the time for it was $100. 377 00:17:47,267 --> 00:17:49,805 People were being sent to compound pharmacies 378 00:17:49,806 --> 00:17:51,809 and paying double what I'm paying. 379 00:17:54,882 --> 00:17:57,486 So I'm doing this on my own. 380 00:17:59,457 --> 00:18:02,429 So my tirzepatide comes from a company 381 00:18:02,430 --> 00:18:05,837 that sources the medication, 382 00:18:05,838 --> 00:18:08,743 just the main ingredient, 383 00:18:08,744 --> 00:18:11,414 and sends it to me in a powdered form. 384 00:18:13,653 --> 00:18:15,556 It comes from China. 385 00:18:15,557 --> 00:18:19,731 Sorry, but the truth is, a lot of them do. 386 00:18:19,732 --> 00:18:23,839 They are marked "For research purposes only." 387 00:18:23,840 --> 00:18:26,177 And when it comes to me in a vial, 388 00:18:26,178 --> 00:18:29,450 I need to use a solution that we call "bac water." 389 00:18:29,451 --> 00:18:31,855 And you mix that into that vial, 390 00:18:31,856 --> 00:18:34,695 and it creates the solution that is your medication. 391 00:18:36,866 --> 00:18:38,869 There's no prescription needed for these. 392 00:18:38,870 --> 00:18:42,610 There's no FDA regulations. 393 00:18:42,611 --> 00:18:45,783 And a lot of us that use peptides, 394 00:18:45,784 --> 00:18:49,290 we are conducting our own research on how it works on us. 395 00:18:52,931 --> 00:18:54,868 So for the tirzepatide peptide, 396 00:18:54,869 --> 00:18:57,708 we pinch the skin for the syringe. 397 00:19:00,413 --> 00:19:03,251 Kraftson: You are injecting something in your body 398 00:19:03,252 --> 00:19:05,890 and you don't-- you don't have a lot of validation 399 00:19:05,891 --> 00:19:08,896 about what it is, how safe it is, 400 00:19:08,897 --> 00:19:11,902 whether it actually is the medicine at all. 401 00:19:12,804 --> 00:19:15,810 Sanchez: I don't need anyone's permission. 402 00:19:15,811 --> 00:19:19,918 This just gets me one step further in my health journey 403 00:19:19,919 --> 00:19:24,628 and feeling better physically, mentally, and emotionally, 404 00:19:24,629 --> 00:19:28,703 because it's no longer this battle that I'll never win. 405 00:19:37,453 --> 00:19:39,290 Woman: Drugs, alcohol, cancer, whatever your problems, people are sympathetic unless you're fat, 406 00:19:39,291 --> 00:19:42,463 and then you're supposed to be ashamed. 407 00:19:42,464 --> 00:19:44,768 Everything's set up to tell you that-- 408 00:19:44,769 --> 00:19:48,274 magazine covers, clothes. 409 00:19:48,275 --> 00:19:52,015 I mean, if you're not thin, you're not neat. 410 00:19:52,016 --> 00:19:53,819 And that's it. 411 00:19:53,820 --> 00:19:55,823 Tovar: I used to believe strongly-- 412 00:19:55,824 --> 00:19:58,529 and I think all larger-body people are encouraged to believe 413 00:19:58,530 --> 00:20:01,602 that our fat body is a temporary body, 414 00:20:01,603 --> 00:20:04,440 and it's an alien body and it's an unwelcome body, 415 00:20:04,441 --> 00:20:07,446 and that there is an authentic, thin person inside of us, 416 00:20:07,447 --> 00:20:09,383 and that that person is real. 417 00:20:11,823 --> 00:20:14,528 But it speaks to this idea 418 00:20:14,529 --> 00:20:18,669 that fat people exist as a product of error. 419 00:20:21,074 --> 00:20:24,681 McMillan Cottom: We still have this really latent assumption 420 00:20:24,682 --> 00:20:27,654 that a body reflects who you really are, 421 00:20:27,655 --> 00:20:30,660 that thin bodies are not just better bodies, 422 00:20:30,661 --> 00:20:34,901 but they are morally superior bodies. 423 00:20:34,902 --> 00:20:37,974 Around, you know, the late 1800s, 424 00:20:37,975 --> 00:20:40,045 we started to see the emergence of the Gibson Girl. 425 00:20:40,046 --> 00:20:42,049 And then that aesthetic got even thinner 426 00:20:42,050 --> 00:20:45,422 with the emergence of the flapper ideal in the 1920s. 427 00:20:45,423 --> 00:20:48,361 We start to see thin bodies selling products. 428 00:20:48,362 --> 00:20:51,668 And that really continued throughout the early 1900s 429 00:20:51,669 --> 00:20:53,506 through the 1960s. 430 00:20:53,507 --> 00:20:56,410 And those were the fashion ideals. 431 00:20:56,411 --> 00:21:00,085 Diet culture is very feminine. It's very white. 432 00:21:00,086 --> 00:21:02,824 It's very focused on things 433 00:21:02,825 --> 00:21:04,728 that straight women are supposed to want 434 00:21:04,729 --> 00:21:06,999 and-- and creating a reality 435 00:21:07,000 --> 00:21:11,340 where weight is a condition of getting those things. 436 00:21:11,341 --> 00:21:13,679 [ Indistinct conversations ] 437 00:21:16,652 --> 00:21:18,354 Man: Watch yourself, fellas. 438 00:21:18,355 --> 00:21:20,325 [ Indistinct conversation ] 439 00:21:20,326 --> 00:21:22,830 Weight Watchers Started in 1963. 440 00:21:22,831 --> 00:21:24,868 It's on this kind of diet that, uh, 441 00:21:24,869 --> 00:21:26,605 you're allowed to lose weight? 442 00:21:26,606 --> 00:21:28,408 Right. As long as they eat it in moderation, 443 00:21:28,409 --> 00:21:30,111 they could have great variety and still lose weight. 444 00:21:30,112 --> 00:21:33,619 And it really pushes diet culture to the forefront. 445 00:21:33,620 --> 00:21:35,355 I guess you went into this together. 446 00:21:35,356 --> 00:21:36,992 We sure did. 447 00:21:36,993 --> 00:21:40,065 We were fat together and we got thin together. 448 00:21:40,066 --> 00:21:42,035 Every woman knows the Weight Watchers model. 449 00:21:42,036 --> 00:21:44,741 Count every single thing that goes into your mouth 450 00:21:44,742 --> 00:21:47,346 and track your weight obsessively. 451 00:21:47,347 --> 00:21:50,118 Rosemary has lost 80 pounds. 452 00:21:50,119 --> 00:21:51,889 Weight Watchers were in schools. 453 00:21:51,890 --> 00:21:55,997 They were in hospitals. They were in workplaces. 454 00:21:55,998 --> 00:21:59,437 You had a Weight Watchers in a strip mall in Idaho. 455 00:22:01,909 --> 00:22:04,480 Sanchez: They would have a weekly meeting. 456 00:22:04,481 --> 00:22:05,883 [ Woman speaks indistinctly ] 457 00:22:05,884 --> 00:22:08,989 And you got weighed where everyone is. 458 00:22:08,990 --> 00:22:11,628 They marked that down on your sheet. 459 00:22:11,629 --> 00:22:15,001 It was something I was told to do. 460 00:22:15,002 --> 00:22:17,707 I hear the name and I just cringe. 461 00:22:17,708 --> 00:22:20,846 Blum: In the '80s, we really start to see this idea 462 00:22:20,847 --> 00:22:24,554 of obesity as a public-health crisis take hold. 463 00:22:24,555 --> 00:22:26,959 And in response, there becomes this sort of 464 00:22:26,960 --> 00:22:30,498 American obsession with cutting fat as much as possible. 465 00:22:30,499 --> 00:22:32,770 Viva tastes so fresh and creamy, 466 00:22:32,771 --> 00:22:34,908 nobody realizes that it's low-fat. 467 00:22:34,909 --> 00:22:36,645 And it's non-fat. 468 00:22:36,646 --> 00:22:38,081 How could this not have any fat? 469 00:22:38,082 --> 00:22:39,784 It's too good. 470 00:22:39,785 --> 00:22:41,420 A lot of the foods in our house were low-fat, 471 00:22:41,421 --> 00:22:44,460 fat-free, and very fake, produced foods. 472 00:22:44,461 --> 00:22:49,036 And I think a lot of that was diet-culture influence 473 00:22:49,037 --> 00:22:51,440 that was pushed at the time. 474 00:22:51,441 --> 00:22:53,779 [ Upbeat music plays ] 475 00:22:56,117 --> 00:22:57,820 Hi, everybody. 476 00:22:57,821 --> 00:23:00,526 This is a very, very personal show for me 477 00:23:00,527 --> 00:23:02,930 because I have received thousands-- 478 00:23:02,931 --> 00:23:04,968 you wouldn't believe the letters 479 00:23:04,969 --> 00:23:06,137 my office has received-- 480 00:23:06,138 --> 00:23:07,874 hundreds of calls every day, 481 00:23:07,875 --> 00:23:09,978 and every place I go out on the street-- 482 00:23:09,979 --> 00:23:13,484 "Hey, Oprah! Okrie girl! 483 00:23:13,485 --> 00:23:15,589 How'd you lose all that weight?" 484 00:23:15,590 --> 00:23:17,492 Gay: Oprah is like all of us. 485 00:23:17,493 --> 00:23:20,533 And that really was what made her audience gravitate. 486 00:23:20,534 --> 00:23:23,471 And the fact that she has publicly struggled with weight 487 00:23:23,472 --> 00:23:25,208 mirrors our private struggles with weight. 488 00:23:25,209 --> 00:23:27,680 You know, "Oh, my gosh. She's just like us, 489 00:23:27,681 --> 00:23:29,483 and she's a billionaire." 490 00:23:29,484 --> 00:23:31,555 You know, I'm tired of having to deal with, 491 00:23:31,556 --> 00:23:35,095 what is wrong with me that I can't solve this problem 492 00:23:35,096 --> 00:23:36,865 that I have with myself? 493 00:23:36,866 --> 00:23:38,468 Harrison: Oprah had incredible pressures on her 494 00:23:38,469 --> 00:23:40,573 to achieve this thin ideal, 495 00:23:40,574 --> 00:23:44,179 and was facing so much scrutiny from tabloids, 496 00:23:44,180 --> 00:23:47,152 from media at large, from other celebrities, even. 497 00:23:47,153 --> 00:23:48,756 They told me you're a beauty-contest winner. 498 00:23:48,757 --> 00:23:50,793 Yeah, uh, 50 pounds ago or so. 499 00:23:50,794 --> 00:23:52,697 So how'd you gain the weight? 500 00:23:52,698 --> 00:23:54,166 I ate a lot. 501 00:23:54,167 --> 00:23:55,970 [ Laughter ] 502 00:23:55,971 --> 00:23:57,907 No, no, no, no, no, no, no. You said 50 pounds. 503 00:23:57,908 --> 00:24:00,011 You shouldn't let that happen to you. 504 00:24:00,012 --> 00:24:01,247 You're very pretty. Joan, do you know what? 505 00:24:01,248 --> 00:24:02,950 No, I don't want to hear. 506 00:24:02,951 --> 00:24:04,688 Let me tell you this. Let me tell you something. 507 00:24:04,689 --> 00:24:05,756 You're a pretty girl and you're single. 508 00:24:05,757 --> 00:24:07,627 You must lose the weight. 509 00:24:07,628 --> 00:24:10,265 But she was also very much a spokesperson for diet culture. 510 00:24:10,266 --> 00:24:12,970 We are now-- "A.M. Chicago," in Chicago-- 511 00:24:12,971 --> 00:24:15,008 we're starting A Diet With Oprah. 512 00:24:15,009 --> 00:24:17,079 - Great. - Yes. 513 00:24:17,080 --> 00:24:19,016 So that I have been put under pressure to finally do it. 514 00:24:19,017 --> 00:24:21,955 And so when she tried something, a lot of people tried it, too. 515 00:24:21,956 --> 00:24:24,527 Today we get the motivation and inspiration we need 516 00:24:24,528 --> 00:24:27,534 to start the Oprah Potato a Day Diet. 517 00:24:29,103 --> 00:24:32,209 McMillan Cottom: No matter what her show was about that Tuesday, 518 00:24:32,210 --> 00:24:35,181 the metanarrative of Oprah's show was, 519 00:24:35,182 --> 00:24:37,720 how happy is she with her body today? 520 00:24:37,721 --> 00:24:39,123 I wake up in the morning. 521 00:24:39,124 --> 00:24:40,693 I go and look in the mirror sometimes, 522 00:24:40,694 --> 00:24:41,962 and one of the reasons why I realized 523 00:24:41,963 --> 00:24:43,565 I don't have a handgun is because 524 00:24:43,566 --> 00:24:45,836 I would have shot off my thighs years ago. 525 00:24:45,837 --> 00:24:48,709 And that metanarrative really shaped 526 00:24:48,710 --> 00:24:52,249 how women in particular talked about themselves... 527 00:24:52,250 --> 00:24:55,556 I start on a diet like I started another one yesterday. 528 00:24:55,557 --> 00:24:58,562 McMillan Cottom: ...the expectations they set for themselves... 529 00:24:58,563 --> 00:25:01,735 I still hate myself because of my weight. 530 00:25:01,736 --> 00:25:03,739 ...and the expectations that they passed on 531 00:25:03,740 --> 00:25:05,308 to their daughters, which I think is also 532 00:25:05,309 --> 00:25:07,680 just particularly complex. 533 00:25:07,681 --> 00:25:09,951 I lost... 534 00:25:09,952 --> 00:25:13,091 I have lost, as of this morning, 535 00:25:13,092 --> 00:25:18,101 as of this morning, 67 pounds since July 7th. 536 00:25:18,102 --> 00:25:21,708 This is what 67 pounds of fat looks like. 537 00:25:21,709 --> 00:25:23,277 Harrison: I think that wagon-of-fat moment 538 00:25:23,278 --> 00:25:25,583 was so iconic, perhaps, 539 00:25:25,584 --> 00:25:29,056 because people had seen her struggle for so long 540 00:25:29,057 --> 00:25:31,862 and, you know, the visual of a wagon of fat, 541 00:25:31,863 --> 00:25:33,932 and I think it sort of taps into that desire of, "Yeah, 542 00:25:33,933 --> 00:25:36,605 if I could just, you know, cut these parts off myself, 543 00:25:36,606 --> 00:25:38,642 I would be okay. I would be perfect." 544 00:25:38,643 --> 00:25:41,280 How do you feel about your girlfriend losing all this weight? 545 00:25:41,281 --> 00:25:43,184 McMillan Cottom: If you watch that whole show, 546 00:25:43,185 --> 00:25:46,725 she brings out her longtime partner, Stedman, 547 00:25:46,726 --> 00:25:50,699 to sort of perform, like, her validation of herself. 548 00:25:50,700 --> 00:25:54,106 Stedman: Since the beginning, every time we walk into a room, 549 00:25:54,107 --> 00:25:56,110 I would see how people would react to you. 550 00:25:56,111 --> 00:25:59,617 And, uh, you know, they-- I could see on their faces, 551 00:25:59,618 --> 00:26:02,389 they said, "Yeah, she's, you know, she's this or she's that, 552 00:26:02,390 --> 00:26:04,226 but she's overweight." 553 00:26:04,227 --> 00:26:05,896 And, you know, I've had to deal with that 554 00:26:05,897 --> 00:26:08,034 for months and months and months. 555 00:26:08,035 --> 00:26:10,104 And I saw, you know-- 556 00:26:10,105 --> 00:26:14,714 I saw, uh, a diamond in the rough. 557 00:26:16,652 --> 00:26:19,122 Harrison: I think she was really, at the time, 558 00:26:19,123 --> 00:26:21,761 like, very pleased and proud. 559 00:26:21,762 --> 00:26:24,667 Diets lure us in. 560 00:26:24,668 --> 00:26:26,805 Every day I mix my little protein pack, 561 00:26:26,806 --> 00:26:29,644 this Optifast. 562 00:26:29,645 --> 00:26:32,048 I drank this five times a day 563 00:26:32,049 --> 00:26:35,054 every day for three and a half months. 564 00:26:35,055 --> 00:26:36,791 But they aren't sustainable, right, 565 00:26:36,792 --> 00:26:38,227 because the body fights weight loss. 566 00:26:38,228 --> 00:26:40,365 Winfrey: In all, I've gained 17 pounds 567 00:26:40,366 --> 00:26:43,672 of the 67 pounds I lost last year. 568 00:26:43,673 --> 00:26:45,743 It is a battle that I'm still fighting 569 00:26:45,744 --> 00:26:49,016 every waking moment of my life. 570 00:26:49,017 --> 00:26:53,057 We want to talk about the toxicity of diet culture, 571 00:26:53,058 --> 00:26:54,928 I think it's important to keep in mind 572 00:26:54,929 --> 00:26:58,000 that not even being a billionaire mega celebrity 573 00:26:58,001 --> 00:27:00,739 bought Oprah Winfrey out of it. 574 00:27:00,740 --> 00:27:03,110 Harrison: And that's really convenient for the diet industry, right? 575 00:27:03,111 --> 00:27:06,217 Because people are dieting their way up the scale, 576 00:27:06,218 --> 00:27:08,221 and they're looking for a new solution. 577 00:27:09,023 --> 00:27:10,158 Dr. Rich: The reality is 578 00:27:10,159 --> 00:27:12,730 there is a medical issue here. 579 00:27:12,731 --> 00:27:15,468 We need to treat people like they have a disease 580 00:27:15,469 --> 00:27:18,140 and not like they are just not strong enough 581 00:27:18,141 --> 00:27:19,945 to say no. 582 00:27:20,647 --> 00:27:23,685 If you can believe in yourself 583 00:27:23,686 --> 00:27:25,789 and believe that this is the most important thing 584 00:27:25,790 --> 00:27:27,727 in your life, you can conquer it. 585 00:27:35,810 --> 00:27:38,281 of people using the GLP-1 medications, 586 00:27:38,282 --> 00:27:41,153 but there is a dark side and we have to talk about it. 587 00:27:41,154 --> 00:27:45,395 It's Friday night, 10:30 p.m. 588 00:27:45,396 --> 00:27:48,200 I'm specifically trying to take it kind of late at night 589 00:27:48,201 --> 00:27:50,204 so that if I have any side effects, 590 00:27:50,205 --> 00:27:52,042 I'll hopefully just sleep through them. 591 00:27:52,043 --> 00:27:54,112 Just grab a little bit of the fat, 592 00:27:54,113 --> 00:27:57,820 which there's plenty of that, and then just boom. 593 00:27:57,821 --> 00:28:00,158 I guess I've been very fortunate with the side effects-- 594 00:28:00,159 --> 00:28:01,962 very minimal. 595 00:28:01,963 --> 00:28:05,268 I have sort of been experiencing, like, heartburn, 596 00:28:05,269 --> 00:28:07,238 um, kind of feeling a bit lately. 597 00:28:07,239 --> 00:28:09,076 I read people's accounts religiously, 598 00:28:09,077 --> 00:28:11,447 and some people reported some truly horrendous things. 599 00:28:11,448 --> 00:28:13,752 I've actually gotten really, really bad. 600 00:28:13,753 --> 00:28:15,488 Like, I'll drink water, 601 00:28:15,489 --> 00:28:17,225 and just, like, immediately have to throw it up. 602 00:28:17,226 --> 00:28:21,968 Nauseous, vomiting, um, hunched over in pain. 603 00:28:21,969 --> 00:28:24,473 Woman: There are rarer reports of pancreatitis 604 00:28:24,474 --> 00:28:27,412 as well as acute kidney injury. 605 00:28:27,413 --> 00:28:30,886 Sanchez: I was lightheaded for a week straight. 606 00:28:30,887 --> 00:28:34,159 And it was affecting my lifts really bad. 607 00:28:34,160 --> 00:28:35,495 Allen: We know what it looks like for people 608 00:28:35,496 --> 00:28:37,365 who have been using them for diabetes, 609 00:28:37,366 --> 00:28:39,937 but we don't know what the longer-term implications are 610 00:28:39,938 --> 00:28:42,242 of being on these medications for weight loss. 611 00:28:42,243 --> 00:28:45,148 [ Grunts ] I thought I was gonna pass out. 612 00:28:45,149 --> 00:28:47,385 Kraftson: Our patients will describe it-- 613 00:28:47,386 --> 00:28:49,156 "Oh, I feel weak," 614 00:28:49,157 --> 00:28:51,995 or, "I don't feel like I have the same stamina." 615 00:28:51,996 --> 00:28:53,464 I... 616 00:28:53,465 --> 00:28:57,974 quickly went to my community on Facebook, 617 00:28:57,975 --> 00:29:00,111 and another lady had the same exact experience. 618 00:29:00,112 --> 00:29:03,384 She goes, "Go back down to 7.5 and you'll feel better," 619 00:29:03,385 --> 00:29:05,054 and I did. 620 00:29:05,055 --> 00:29:06,524 Kraftson: And when you lose a lot of weight, 621 00:29:06,525 --> 00:29:08,194 you just hope, "Oh, it's all gonna be fat." 622 00:29:08,195 --> 00:29:11,868 But that is actually not what happens. 623 00:29:11,869 --> 00:29:16,845 We are worried about that muscle loss that can happen. 624 00:29:16,846 --> 00:29:21,855 ♪ 625 00:29:21,856 --> 00:29:23,190 Luxmore: There's more studies coming out. 626 00:29:23,191 --> 00:29:24,861 They're talking about longer-- 627 00:29:24,862 --> 00:29:27,332 longer effects of being on these medications. 628 00:29:27,333 --> 00:29:29,837 And, you know, I'm thinking about like, 629 00:29:29,838 --> 00:29:32,208 "Oh, am I gonna take this medication forever? 630 00:29:32,209 --> 00:29:34,279 Is that fine?" 631 00:29:34,280 --> 00:29:36,584 My early days of thinking about GLP-1 drugs was, 632 00:29:36,585 --> 00:29:38,588 "Oh, I remember this. 633 00:29:38,589 --> 00:29:41,360 We've done this before." 634 00:29:41,361 --> 00:29:44,166 Reporter: Wouldn't it be nice to treat obesity with a pill? 635 00:29:44,167 --> 00:29:46,036 Now we can. 636 00:29:46,037 --> 00:29:48,542 Two drugs, fenfluramine and phentermine, 637 00:29:48,543 --> 00:29:51,380 when taken together, help you control your appetite. 638 00:29:51,381 --> 00:29:53,217 The program is called Fen-Phen. 639 00:29:53,218 --> 00:29:55,856 By giving them the pills, it makes them not hungry, 640 00:29:55,857 --> 00:29:57,927 and it makes them satiated. 641 00:29:57,928 --> 00:29:59,597 ♪ 642 00:29:59,598 --> 00:30:02,536 Dr. Rich: Fenfluramine... 643 00:30:02,537 --> 00:30:06,845 which is one of the drugs in the Fen-Phen name... 644 00:30:06,846 --> 00:30:10,151 was a drug developed by Servier Pharmaceuticals, 645 00:30:10,152 --> 00:30:12,255 a French pharmaceutical company. 646 00:30:12,256 --> 00:30:14,025 ♪ 647 00:30:14,026 --> 00:30:16,163 But women taking the fenfluramine 648 00:30:16,164 --> 00:30:18,902 started to develop pulmonary hypertension, 649 00:30:18,903 --> 00:30:21,206 which is a cause of serious heart failure. 650 00:30:21,207 --> 00:30:23,444 ♪ 651 00:30:23,445 --> 00:30:26,918 Well, Servier pushed back, and they said, 652 00:30:26,919 --> 00:30:29,222 "We're not going to take this off the market 653 00:30:29,223 --> 00:30:30,993 unless there's proof." 654 00:30:30,994 --> 00:30:33,497 So the health authorities in Europe 655 00:30:33,498 --> 00:30:36,470 agreed with Servier to put together a plan 656 00:30:36,471 --> 00:30:38,942 for an epidemiologic study. 657 00:30:38,943 --> 00:30:40,311 ♪ 658 00:30:40,312 --> 00:30:42,883 At the end of the trial, 659 00:30:42,884 --> 00:30:46,925 we've showed what's the chance of you getting this disease 660 00:30:46,926 --> 00:30:49,063 if you take these diet pills. 661 00:30:50,099 --> 00:30:53,104 So, the odds ratio-- to give you some comparisons-- 662 00:30:53,105 --> 00:30:55,676 the odds ratio for lung cancer and cigarette smoking 663 00:30:55,677 --> 00:30:57,379 would be about four. 664 00:30:58,181 --> 00:31:01,386 In general, you are four times more likely 665 00:31:01,387 --> 00:31:04,459 to get lung cancer if you smoke than if you don't. 666 00:31:04,460 --> 00:31:07,700 The odds ratio for severe pulmonary hypertension 667 00:31:07,701 --> 00:31:09,570 was 23... 668 00:31:09,571 --> 00:31:11,908 with 3 months' exposure. 669 00:31:12,710 --> 00:31:15,682 But Servier's partner in the United States 670 00:31:15,683 --> 00:31:18,688 had a subsidiary called Wyeth-Ayerst. 671 00:31:18,689 --> 00:31:21,427 They went to the FDA to get the drug approved. 672 00:31:22,630 --> 00:31:26,236 So the FDA asked me to present the data 673 00:31:26,237 --> 00:31:28,708 from the European study. 674 00:31:28,709 --> 00:31:32,650 And then it passed, 6 to 5, to get this drug on the market. 675 00:31:33,552 --> 00:31:35,054 I don't crave anything. 676 00:31:35,055 --> 00:31:36,558 My most successful patient has lost 677 00:31:36,559 --> 00:31:38,360 over 100 pounds in a year. 678 00:31:38,361 --> 00:31:41,033 Reporter: Gary dropped from size 44 to 36. 679 00:31:41,034 --> 00:31:43,370 Woman: I tried all kinds of diets all my life. 680 00:31:43,371 --> 00:31:45,374 [ Microwave dings ] Hmm. 681 00:31:45,375 --> 00:31:46,711 Woman: This is the first time I've been able to keep it off. 682 00:31:46,712 --> 00:31:48,582 Everyone wanted on. 683 00:31:48,583 --> 00:31:49,951 Woman: I have a lot more self-esteem. 684 00:31:49,952 --> 00:31:51,487 I have a lot more energy. 685 00:31:51,488 --> 00:31:53,290 My bowling average has gone up 10 pins. 686 00:31:53,291 --> 00:31:55,261 It was skyrocketing. 687 00:31:55,262 --> 00:31:56,664 We're definitely seeing a revolution 688 00:31:56,665 --> 00:31:58,467 in the way we think about obesity. 689 00:31:58,468 --> 00:32:00,371 Dr. Rich: I mean, it was devastating to me 690 00:32:00,372 --> 00:32:03,210 because I knew, from the patients' side, 691 00:32:03,211 --> 00:32:05,348 what the consequence of this was going to be. 692 00:32:05,349 --> 00:32:06,751 It's 7:19 now. 693 00:32:06,752 --> 00:32:08,187 Once again, here's Bryant in Chicago. 694 00:32:08,188 --> 00:32:09,724 All right, Katie. Thanks. 695 00:32:09,725 --> 00:32:12,161 Of late, more than 60,000 new customers a week 696 00:32:12,162 --> 00:32:15,301 have taken to trying the newest trendy diet. 697 00:32:15,302 --> 00:32:17,305 The diet is called Fen-Phen. 698 00:32:17,306 --> 00:32:19,710 Problem is, those pills could also be linked to a serious 699 00:32:19,711 --> 00:32:21,480 and sometimes fatal lung disease. 700 00:32:21,481 --> 00:32:23,317 That news comes from a study published today 701 00:32:23,318 --> 00:32:24,754 in "The New England Journal of Medicine." 702 00:32:24,755 --> 00:32:26,490 Dr. Stuart Rich from the University of Illinois 703 00:32:26,491 --> 00:32:28,160 is one of those who authored that study. 704 00:32:28,161 --> 00:32:29,597 Doctor, welcome. 705 00:32:29,598 --> 00:32:31,734 This drug produces. Pulmonary hypertension, 706 00:32:31,735 --> 00:32:34,272 a very uncommon but very fatal illness. 707 00:32:34,273 --> 00:32:37,011 Dr. Rich: When I appeared on the "Today" show, 708 00:32:37,012 --> 00:32:38,582 the drug was just on the market, 709 00:32:38,583 --> 00:32:41,621 being hailed as the Great American Dream. 710 00:32:41,622 --> 00:32:45,127 Would it be fair to say that even with the increased risks, 711 00:32:45,128 --> 00:32:46,664 the chance is minuscule? 712 00:32:46,665 --> 00:32:48,668 No, far from minuscule. 713 00:32:48,669 --> 00:32:52,075 So now physicians were really confused. 714 00:32:52,777 --> 00:32:55,047 This drug got approved, and here's this paper 715 00:32:55,048 --> 00:32:58,722 in "The New England Journal" saying it's not so safe? 716 00:32:58,723 --> 00:33:00,358 Lauer: Cardiologists at the Mayo Clinic 717 00:33:00,359 --> 00:33:02,630 have found that 24 women on these drugs 718 00:33:02,631 --> 00:33:04,232 developed some severe heart problems. 719 00:33:04,233 --> 00:33:06,103 Dr. Rich: And it didn't take too long 720 00:33:06,104 --> 00:33:07,706 before there was another paper 721 00:33:07,707 --> 00:33:10,512 showing damage to the heart from these diet pills 722 00:33:10,513 --> 00:33:12,616 that came out of the Mayo Clinic. 723 00:33:12,617 --> 00:33:16,691 They knew that they had far more cases of pulmonary hypertension 724 00:33:16,692 --> 00:33:18,561 and deaths associated with that 725 00:33:18,562 --> 00:33:20,464 than they told the doctors about. 726 00:33:20,465 --> 00:33:22,235 There are figures coming out, four or five deaths. 727 00:33:22,236 --> 00:33:24,172 Don't use it. It's a deadly drug. 728 00:33:24,173 --> 00:33:26,443 Reporter: She took the drug for just a few weeks 729 00:33:26,444 --> 00:33:28,380 when her symptoms began. 730 00:33:28,381 --> 00:33:31,654 Nearly nine months later, she was dead. 731 00:33:31,655 --> 00:33:33,290 ♪ 732 00:33:33,291 --> 00:33:34,694 It was the nail in the coffin. 733 00:33:34,695 --> 00:33:38,233 ♪ 734 00:33:38,234 --> 00:33:42,208 I remember there was a woman in my community here 735 00:33:42,209 --> 00:33:44,313 who was on Fen-Phen... 736 00:33:45,048 --> 00:33:48,387 ...who stopped me on the street and yelled at me 737 00:33:48,388 --> 00:33:50,859 that I was the reason why 738 00:33:50,860 --> 00:33:54,265 she couldn't take her diet pill any longer. 739 00:33:54,266 --> 00:33:58,107 How dare I be part of all of this? 740 00:33:58,709 --> 00:34:00,646 McMillan Cottom: Imagine what it means to say 741 00:34:00,647 --> 00:34:04,152 it is more important for you to risk dying 742 00:34:04,153 --> 00:34:08,528 than it is for you to live being obese. 743 00:34:08,529 --> 00:34:11,567 Man: A new lawsuit is alleging that some diabetes drugs, 744 00:34:11,568 --> 00:34:13,370 which have become popular for their weight-loss effects, 745 00:34:13,371 --> 00:34:16,209 are causing stomach paralysis in some users. 746 00:34:16,210 --> 00:34:17,780 Man #2: Their symptoms are so difficult to control 747 00:34:17,781 --> 00:34:20,284 that they have to be admitted to the hospital. 748 00:34:20,285 --> 00:34:21,888 Luxmore: And I mentioned before 749 00:34:21,889 --> 00:34:24,159 that I had felt a little, like, heartburn. 750 00:34:24,160 --> 00:34:25,595 And other people have reported that, too, 751 00:34:25,596 --> 00:34:27,398 and it was pretty minor, 752 00:34:27,399 --> 00:34:29,637 but it actually-- I kind of, like, enjoyed that 753 00:34:29,638 --> 00:34:31,306 I had a little bit of heartburn. 754 00:34:31,307 --> 00:34:33,645 I was like, "Ah, that's the medication, man." 755 00:34:33,646 --> 00:34:35,749 There's so many questions, you know, 756 00:34:35,750 --> 00:34:38,120 about what's gonna happen over the long-term. 757 00:34:41,394 --> 00:34:43,865 I honestly don't even care about the long-term effects. 758 00:34:43,866 --> 00:34:45,902 And that's really where I'm at today is like, okay, 759 00:34:45,903 --> 00:34:48,340 let's say in five years I have stomach cancer and it's bad, 760 00:34:48,341 --> 00:34:50,378 like, I had a good run. 761 00:34:50,379 --> 00:34:52,583 Like, I'm assuming that I can just be normal for a while. 762 00:34:52,584 --> 00:34:57,425 Like, I would take that if it meant a terrible ending. 763 00:34:57,426 --> 00:35:00,566 It's more like, okay, let's just see what happens, you know? 764 00:35:10,218 --> 00:35:12,623 [ Woman speaks indistinctly ] 765 00:35:16,832 --> 00:35:18,601 Arrellin: My lizard's name is Buford, 766 00:35:18,602 --> 00:35:21,674 and he's a citrus bearded dragon. 767 00:35:21,675 --> 00:35:24,312 He's so, so pretty. I love him. 768 00:35:24,313 --> 00:35:28,220 I feed him this vegetable mix that he really likes. 769 00:35:28,221 --> 00:35:30,191 I feed him-- I don't know what they're called, 770 00:35:30,192 --> 00:35:32,228 but they're little worms and they're blue, 771 00:35:32,229 --> 00:35:36,169 and they explode when they bite them. 772 00:35:36,170 --> 00:35:39,242 My name is Jennavecia, and I'm 14 years old. 773 00:35:42,382 --> 00:35:45,722 I was 10 when I was diagnosed with PCOS. 774 00:35:45,723 --> 00:35:47,492 ♪ 775 00:35:47,493 --> 00:35:50,966 You have more testosterone than most women. 776 00:35:50,967 --> 00:35:55,207 It intensifies hair growth and acne 777 00:35:55,208 --> 00:35:57,445 and weight gain. 778 00:35:57,446 --> 00:36:00,519 And everything that nobody wants to deal with 779 00:36:00,520 --> 00:36:01,788 is what we get. 780 00:36:01,789 --> 00:36:03,792 ♪ 781 00:36:03,793 --> 00:36:07,933 When I first started to notice that I was gaining weight, 782 00:36:07,934 --> 00:36:10,639 I cried. I cried so much. 783 00:36:10,640 --> 00:36:14,379 I was super self-conscious, was not comfortable in my own skin. 784 00:36:14,380 --> 00:36:16,784 So after a while I, like, avoided going swimming, 785 00:36:16,785 --> 00:36:19,255 I avoided doing so, so, so much 786 00:36:19,256 --> 00:36:21,259 because I didn't like how it looked. 787 00:36:21,260 --> 00:36:23,531 I look like Satan in that. This one? 788 00:36:23,532 --> 00:36:27,539 Yes. You're actually ungodly excited at that point. 789 00:36:27,540 --> 00:36:30,946 Hernandez: I, too, had struggled with my weight. 790 00:36:30,947 --> 00:36:34,018 My perception on weight was very, um, jaded. 791 00:36:34,019 --> 00:36:35,822 It was terrible. 792 00:36:35,823 --> 00:36:37,693 What if I told you that in 10 days 793 00:36:37,694 --> 00:36:39,663 you could lose two inches around your waist 794 00:36:39,664 --> 00:36:41,266 and drop a dress size? 795 00:36:41,267 --> 00:36:42,970 Dr. Mehmet Oz is back, 796 00:36:42,971 --> 00:36:45,609 and he claims he has the real weapon against fat. 797 00:36:45,610 --> 00:36:49,784 In the 2000s, it was very unrealistic, the way 798 00:36:49,785 --> 00:36:52,890 that they were trying to have women look, 799 00:36:52,891 --> 00:36:54,693 especially to teenagers. 800 00:36:54,694 --> 00:36:56,798 You know Natalie, who works here? 801 00:36:56,799 --> 00:36:58,935 Woman: The chubby girl? 802 00:36:58,936 --> 00:37:00,839 Ooh, would call her chubby? 803 00:37:00,840 --> 00:37:02,576 Hernandez: I ended up developing 804 00:37:02,577 --> 00:37:04,580 anorexia and stuff through those years. 805 00:37:04,581 --> 00:37:05,982 Reporter: Now it looks like Jess is enjoying 806 00:37:05,983 --> 00:37:08,287 a whole lot of Southern cooking. 807 00:37:08,288 --> 00:37:09,723 - I know what you're saying. - What am I saying? 808 00:37:09,724 --> 00:37:11,527 - That I'm overweight. - You really are. 809 00:37:11,528 --> 00:37:15,000 - How much does she weigh? - 350 pounds. 810 00:37:15,001 --> 00:37:17,840 On TV, you are a little fuller, a little bit more thicker. 811 00:37:17,841 --> 00:37:20,411 I wouldn't call myself thick. I'm just standing next to Paris 812 00:37:20,412 --> 00:37:21,848 who's the skinniest person in the world. 813 00:37:21,849 --> 00:37:23,818 There's a wealth of research that shows that 814 00:37:23,819 --> 00:37:26,724 the more the toxic culture of the 2000s 815 00:37:26,725 --> 00:37:31,066 really took hold on television and later on social media... 816 00:37:31,067 --> 00:37:32,870 Is your weight back to normal? 817 00:37:32,871 --> 00:37:34,472 - Yeah, it is. - Can I check? Do you mind? 818 00:37:34,473 --> 00:37:36,309 Blum: ...the more that young girls started 819 00:37:36,310 --> 00:37:38,681 to develop eating disorders. 820 00:37:38,682 --> 00:37:41,453 You know, I remember Pro-Ana Tumblr 821 00:37:41,454 --> 00:37:44,092 and just the total way in which young girls 822 00:37:44,093 --> 00:37:47,599 were sharing their strategies, 823 00:37:47,600 --> 00:37:50,939 what tools to use to make yourself as skinny as possible. 824 00:37:53,645 --> 00:37:56,684 It was really damaging and pervasive. 825 00:37:58,589 --> 00:38:00,424 I know for me personally, when I was struggling 826 00:38:00,425 --> 00:38:03,865 with my own eating disorder around that time, 827 00:38:03,866 --> 00:38:05,902 it was just the sense I could never be thin enough, 828 00:38:05,903 --> 00:38:10,344 and I did not see myself clearly. 829 00:38:10,345 --> 00:38:11,981 But I think it happened to so many of us 830 00:38:11,982 --> 00:38:14,887 in our society, like, en masse around that time. 831 00:38:17,058 --> 00:38:20,064 Tovar: You know, pretty early on I'm starting to restrict food, 832 00:38:20,065 --> 00:38:22,068 and the behavior gets worse over time, 833 00:38:22,069 --> 00:38:24,640 and I'm just restricting more and more and more. 834 00:38:24,641 --> 00:38:26,978 I hate my body. I literally wake up every day 835 00:38:26,979 --> 00:38:28,581 and I'm like, "I hate this body. 836 00:38:28,582 --> 00:38:30,351 I will do anything not to have this body." 837 00:38:30,352 --> 00:38:33,625 It's not like it was just my peers or just my doctor. 838 00:38:33,626 --> 00:38:37,064 It was, like, my peers, the doctor, the media, 839 00:38:37,065 --> 00:38:39,002 everything I was watching. 840 00:38:39,003 --> 00:38:43,645 Unless you faint, puke, or die, keep walking! 841 00:38:43,646 --> 00:38:45,080 Go, go, go! 842 00:38:45,081 --> 00:38:46,951 I want you to run through the pain. 843 00:38:46,952 --> 00:38:50,959 They've helped 114 people lose over 10,000 pounds. 844 00:38:50,960 --> 00:38:52,763 Man: I literally was just like, 845 00:38:52,764 --> 00:38:55,167 "I have got my work cut out for me right now." 846 00:38:55,168 --> 00:38:57,071 Woman: Kathy's plan features liposuction 847 00:38:57,072 --> 00:38:58,541 in six different areas. 848 00:38:58,542 --> 00:39:00,144 No more cookies. Say it every time. 849 00:39:00,145 --> 00:39:02,081 No more cookies! 850 00:39:02,082 --> 00:39:03,818 McMillan Cottom: Then there's the social-media revolution. 851 00:39:03,819 --> 00:39:05,689 ...the fastest way to lose 30 pounds. 852 00:39:05,690 --> 00:39:07,024 For breakfast, I'm having half of a large watermelon. 853 00:39:07,025 --> 00:39:09,763 Four six-ounce tri-tip sirloin steaks. 854 00:39:09,764 --> 00:39:13,437 The Internet overall amplified diet culture. 855 00:39:13,438 --> 00:39:15,441 If you want to lose weight and you don't know where to start, 856 00:39:15,442 --> 00:39:16,844 listen to this. 857 00:39:16,845 --> 00:39:18,548 McMillan Cottom: And it's also made it harder 858 00:39:18,549 --> 00:39:21,587 to regulate and rein in. 859 00:39:21,588 --> 00:39:23,658 Man: This is day two of trying to lose 35 pounds 860 00:39:23,659 --> 00:39:26,096 of water weight in one single day. 861 00:39:26,097 --> 00:39:28,467 Blum: It's like you can never really get away 862 00:39:28,468 --> 00:39:29,970 from this narrative 863 00:39:29,971 --> 00:39:31,707 that is telling you the worst thing you can be 864 00:39:31,708 --> 00:39:33,678 is someone in a larger body. 865 00:39:36,718 --> 00:39:40,725 Hernandez: It hurt to see my daughter 866 00:39:40,726 --> 00:39:43,998 go through being bullied 867 00:39:43,999 --> 00:39:47,706 for those things that she couldn't control. 868 00:39:47,707 --> 00:39:49,710 Arrellin: It was the boys. 869 00:39:49,711 --> 00:39:51,714 They were honestly the worst part of it. 870 00:39:51,715 --> 00:39:54,218 I remember specifically, I was in eighth grade 871 00:39:54,219 --> 00:39:57,993 and I walked my friend home, and he drove by and he was like, 872 00:39:57,994 --> 00:40:01,032 he yelled out the window, "Fat," 873 00:40:01,033 --> 00:40:03,437 very unkind word, the B-word. 874 00:40:03,438 --> 00:40:04,940 And I was like, "Well, that's mean. 875 00:40:04,941 --> 00:40:07,144 I don't even know you." 876 00:40:07,145 --> 00:40:08,881 Reporter: The FDA approving Wegovy 877 00:40:08,882 --> 00:40:11,620 as a treatment for teenagers with obesity. 878 00:40:11,621 --> 00:40:13,490 Reporter #2: Drugs for weight loss now being prescribed 879 00:40:13,491 --> 00:40:16,096 to kids as young as 12. 880 00:40:16,097 --> 00:40:18,634 Arrellin: The test study that I am in right now 881 00:40:18,635 --> 00:40:22,475 is the Wegovy test study. 882 00:40:22,476 --> 00:40:25,515 My doctor is trying to-- 883 00:40:25,516 --> 00:40:29,590 she's trying everything she can to make it better for me. 884 00:40:31,060 --> 00:40:33,497 Jenny, come on back. 885 00:40:33,498 --> 00:40:35,769 So we're just gonna grab your height and weight. 886 00:40:35,770 --> 00:40:39,008 Cree: Adult women with PCOS who struggle with weight 887 00:40:39,009 --> 00:40:42,481 have an eight times higher rate of developing type-two diabetes. 888 00:40:42,482 --> 00:40:45,622 So the number-one recommendation for PCOS 889 00:40:45,623 --> 00:40:47,659 is weight loss. 890 00:40:47,660 --> 00:40:50,799 Hernandez: We had a sense of hope. 891 00:40:50,800 --> 00:40:53,237 Not relief yet, but hope. 892 00:40:57,813 --> 00:41:00,150 Arrellin: My first time on Wegovy shot, 893 00:41:00,151 --> 00:41:01,620 I think it hurt really bad. 894 00:41:01,621 --> 00:41:04,225 It's 8:05 p.m., 895 00:41:04,226 --> 00:41:08,067 and I'm about to take my shot of Wegovy. 896 00:41:09,202 --> 00:41:10,739 [ Gasps ] 897 00:41:10,740 --> 00:41:12,743 I would not leave my bed. It was terrible. 898 00:41:12,744 --> 00:41:14,680 It was just all puke. 899 00:41:14,681 --> 00:41:16,282 I couldn't eat. I couldn't drink. It was bad. 900 00:41:16,283 --> 00:41:18,621 All right. 901 00:41:18,622 --> 00:41:21,794 So you said you're having the sweating and the shaking, 902 00:41:21,795 --> 00:41:23,698 but it's mostly before meals? 903 00:41:23,699 --> 00:41:26,537 Cree: One of the concerns for the GLP-1s 904 00:41:26,538 --> 00:41:29,810 is the amount of time 905 00:41:29,811 --> 00:41:32,047 that somebody would be on these medications. 906 00:41:32,048 --> 00:41:33,316 Well, it's actually so sad. 907 00:41:33,317 --> 00:41:35,254 My favorite food-- um, we went to 908 00:41:35,255 --> 00:41:37,993 a Mexican restaurant and I got flautas. 909 00:41:37,994 --> 00:41:39,262 They were so gross. I was so sad. 910 00:41:39,263 --> 00:41:41,132 I love flautas. 911 00:41:41,133 --> 00:41:42,602 Looks like the part of your brain 912 00:41:42,603 --> 00:41:44,573 where you make those decisions, 913 00:41:44,574 --> 00:41:48,848 um, it's changed relative to where you take your calories in. 914 00:41:48,849 --> 00:41:53,724 Are we actually rewiring the brain 915 00:41:53,725 --> 00:41:56,931 in a developing individual? 916 00:41:56,932 --> 00:41:59,001 And what does this do long-term? 917 00:41:59,002 --> 00:42:02,274 We just don't know. 918 00:42:02,275 --> 00:42:04,145 Cree: Do you want to know how much weight you've lost? 919 00:42:04,146 --> 00:42:05,748 - Yeah. - Yes. 920 00:42:05,749 --> 00:42:10,692 Today you are 86.3 kilos. 921 00:42:10,693 --> 00:42:11,861 You've lost 10 pounds. 922 00:42:11,862 --> 00:42:13,163 Oh, my God. I did it. 923 00:42:13,164 --> 00:42:14,967 That is good. 924 00:42:14,968 --> 00:42:19,710 Arrellin: The Wegovy test-study trial is 10 months long. 925 00:42:19,711 --> 00:42:24,686 If I keep on what I'm doing now, I will be a lot healthier. 926 00:42:24,687 --> 00:42:27,024 I'll be better. I'll be amazing. 927 00:42:27,025 --> 00:42:30,164 But my fear is that all of my progress 928 00:42:30,165 --> 00:42:33,871 that I've made on the Wegovy could just disappear 929 00:42:33,872 --> 00:42:36,309 after I get off of it. 930 00:42:36,310 --> 00:42:38,180 I think that's it for me. 931 00:42:38,181 --> 00:42:41,319 That means we're ready to go up on the next doses. 932 00:42:41,320 --> 00:42:43,658 Do you feel ready to go up on the next doses? Mm-hmm. 933 00:42:43,659 --> 00:42:45,995 Arrellin: I'm scared of that. 934 00:42:45,996 --> 00:42:49,035 I'm scared of doing all of this for nothing at the end. 935 00:43:03,063 --> 00:43:05,835 Arrellin: I have more motivation to do things around the house. 936 00:43:05,836 --> 00:43:07,338 I love cooking and cleaning now. 937 00:43:07,339 --> 00:43:09,175 It's, like, my favorite thing to do, ever. 938 00:43:10,979 --> 00:43:12,381 And sometimes I make, like, a little dessert. 939 00:43:12,382 --> 00:43:14,653 It's great. I don't ever eat the dessert. 940 00:43:14,654 --> 00:43:17,659 But everybody else likes it, so that makes me happy. 941 00:43:17,660 --> 00:43:22,368 ♪ 942 00:43:22,369 --> 00:43:24,372 We went grocery shopping earlier. 943 00:43:24,373 --> 00:43:28,079 Publix had these shrimp trays-- buy one, get one. 944 00:43:28,080 --> 00:43:32,354 Readily available, ready to go, low-calorie, high-ish protein. 945 00:43:32,355 --> 00:43:34,693 $10 a tray. Not bad. 946 00:43:34,694 --> 00:43:37,966 What I'm having is a bowl 947 00:43:37,967 --> 00:43:39,970 with, uh, some super greens, 948 00:43:39,971 --> 00:43:41,372 some green-bean chicken. 949 00:43:41,373 --> 00:43:43,711 I'm going to have a fortune cookie. 950 00:43:43,712 --> 00:43:46,049 I love fortune cookies. 951 00:43:49,022 --> 00:43:51,994 The part of Pueblo that I live in, 952 00:43:51,995 --> 00:43:54,833 it's technically like a borough town. 953 00:43:54,834 --> 00:43:57,338 It's not fully connected, but it's connected. 954 00:43:57,339 --> 00:44:01,847 Here itself, there's not that much. 955 00:44:01,848 --> 00:44:04,352 There's a little restaurant up the street from the house, 956 00:44:04,353 --> 00:44:08,026 which is, like, an hour and a half, hour walk. 957 00:44:08,027 --> 00:44:09,295 Man on TV: The term "food desert" 958 00:44:09,296 --> 00:44:12,001 is used to describe neighborhoods 959 00:44:12,002 --> 00:44:14,038 where there are few, if any, markets 960 00:44:14,039 --> 00:44:18,247 to buy fresh and nutritious food at a reasonable price. 961 00:44:21,219 --> 00:44:26,029 McMillan Cottom: GLP-1s are a blockbuster 962 00:44:26,030 --> 00:44:28,935 because they promise to solve a social problem 963 00:44:28,936 --> 00:44:31,139 without changing anything else. 964 00:44:31,140 --> 00:44:33,410 It is the height of hypocrisy 965 00:44:33,411 --> 00:44:36,750 that American social policy, 966 00:44:36,751 --> 00:44:41,459 from everything from housing to transportation to agriculture, 967 00:44:41,460 --> 00:44:45,200 incentivizes things that make it difficult 968 00:44:45,201 --> 00:44:46,804 for people to be healthy. 969 00:44:46,805 --> 00:44:51,045 Good morning. 970 00:44:51,046 --> 00:44:54,953 Cardiovascular heart disease is the leading cause of deat h 971 00:44:54,954 --> 00:44:56,790 in the United States today, 972 00:44:56,791 --> 00:45:00,932 and costs society over $60 billion in direct 973 00:45:00,933 --> 00:45:03,904 and indirect health costs each year. 974 00:45:03,905 --> 00:45:06,175 Blum: Over the years, 975 00:45:06,176 --> 00:45:08,280 the government has rolled out a number of different programs 976 00:45:08,281 --> 00:45:10,785 to try to get more involved in people's health. 977 00:45:10,786 --> 00:45:12,488 Metzenbaum: I do look at labels, 978 00:45:12,489 --> 00:45:14,893 and I'm more confused every time I look at them. 979 00:45:14,894 --> 00:45:17,832 People who represent industry have an obligation 980 00:45:17,833 --> 00:45:21,339 to be concerned about the health of the people of this country. 981 00:45:21,340 --> 00:45:23,243 And there have been some changes. 982 00:45:23,244 --> 00:45:27,084 The idea is that they will put the nutrition information 983 00:45:27,085 --> 00:45:30,223 out for the consumer at fast-food restaurants. 984 00:45:30,224 --> 00:45:32,328 There was Let's Move, Michelle Obama's campaign 985 00:45:32,329 --> 00:45:35,067 to try to increase physical activity. 986 00:45:35,068 --> 00:45:38,774 We can't afford not to give our kids nutritious food. 987 00:45:38,775 --> 00:45:39,943 Harrison: It was so tied to rhetoric 988 00:45:39,944 --> 00:45:41,479 around the obesity epidemic 989 00:45:41,480 --> 00:45:44,485 and how this initiative was going to help ameliorate it. 990 00:45:44,486 --> 00:45:46,222 Man on TV: The public-health purpose 991 00:45:46,223 --> 00:45:48,828 is to get consumers to make healthier choices. 992 00:45:48,829 --> 00:45:51,366 Kraftson: We need a lot more encouragement to people 993 00:45:51,367 --> 00:45:53,971 to choose healthier diets. 994 00:45:53,972 --> 00:45:55,942 McMillan Cottom: You can make all the individual changes 995 00:45:55,943 --> 00:45:57,344 that you want, 996 00:45:57,345 --> 00:45:59,215 but if the environment makes it easier 997 00:45:59,216 --> 00:46:02,989 for you to eat more calories and to move less, 998 00:46:02,990 --> 00:46:05,360 then it is not an individual problem. 999 00:46:05,361 --> 00:46:07,398 And when we come up with individual solutions 1000 00:46:07,399 --> 00:46:12,007 and put people in a catch-22 of available options, 1001 00:46:12,008 --> 00:46:14,378 then we create the system that blames people 1002 00:46:14,379 --> 00:46:17,284 for things that really are beyond their control. 1003 00:46:17,285 --> 00:46:19,021 Before I had any critical awareness 1004 00:46:19,022 --> 00:46:20,958 of weight discrimination or diet culture, 1005 00:46:20,959 --> 00:46:24,432 I used to listen avidly to any advice about eating. 1006 00:46:24,433 --> 00:46:27,004 We don't need more advice on how to eat. 1007 00:46:27,005 --> 00:46:29,275 No more rules, no more advice. 1008 00:46:29,276 --> 00:46:34,018 We need less of the stuff that actually harms people. 1009 00:46:34,019 --> 00:46:37,892 One of the most powerful things that social media did 1010 00:46:37,893 --> 00:46:41,567 was to basically create a reality 1011 00:46:41,568 --> 00:46:45,407 in which larger-bodied people could be the authors 1012 00:46:45,408 --> 00:46:48,514 of their own story for the first time in history, 1013 00:46:48,515 --> 00:46:52,555 and it created enough space to say, "Oh, my God, 1014 00:46:52,556 --> 00:46:55,293 if this plus-size woman is showing me 1015 00:46:55,294 --> 00:46:57,431 that they're dating and wearing cute bikinis 1016 00:46:57,432 --> 00:46:59,301 and going, like, on trips 1017 00:46:59,302 --> 00:47:01,305 and having these meaningful moments, 1018 00:47:01,306 --> 00:47:04,044 it was just like it was a cognitive dissonance 1019 00:47:04,045 --> 00:47:07,151 because I've been told there's no path to dignity, 1020 00:47:07,152 --> 00:47:10,958 no path to love, no path to beauty." 1021 00:47:10,959 --> 00:47:14,599 I don't starve myself. 1022 00:47:14,600 --> 00:47:16,102 Luxmore: You know, I want to be very supportive of people, 1023 00:47:16,103 --> 00:47:17,404 and I am very supportive of people. 1024 00:47:17,405 --> 00:47:18,874 Like. other people who are large, 1025 00:47:18,875 --> 00:47:21,012 like, I understand their experience 1026 00:47:21,013 --> 00:47:22,582 and I want to support them. 1027 00:47:22,583 --> 00:47:24,185 But when I think about body positivity, for me, 1028 00:47:24,186 --> 00:47:25,922 like, it doesn't apply. 1029 00:47:25,923 --> 00:47:27,491 So if somebody came at me with body positivity, 1030 00:47:27,492 --> 00:47:29,095 like, "You just need to feel better about yourself," 1031 00:47:29,096 --> 00:47:30,898 I'd be like, "You need to go fuck off." 1032 00:47:30,899 --> 00:47:33,470 I started getting e-mail 1033 00:47:33,471 --> 00:47:37,377 from third-party marketing companies 1034 00:47:37,378 --> 00:47:41,620 that wanted me to take GLP-1s 1035 00:47:41,621 --> 00:47:44,058 and share my journey. 1036 00:47:44,059 --> 00:47:49,068 What made it noteworthy to me was if they vetted my platform, 1037 00:47:49,069 --> 00:47:52,441 they either don't care about my values 1038 00:47:52,442 --> 00:47:54,646 or they actually believe I'm lying. 1039 00:47:54,647 --> 00:47:57,652 There was a cynicism that felt very familiar 1040 00:47:57,653 --> 00:48:00,390 and it also felt very toxic. 1041 00:48:00,391 --> 00:48:05,333 What GLP-1 did is that it made everybody prove 1042 00:48:05,334 --> 00:48:07,639 just how body-positive they were. 1043 00:48:07,640 --> 00:48:10,110 I don't like people complimenting 1044 00:48:10,111 --> 00:48:12,949 or not complimenting on how you look. 1045 00:48:12,950 --> 00:48:16,255 Having said that, I welcome you to call me a skinny bitch. 1046 00:48:16,256 --> 00:48:17,959 McMillan Cottom: It is something else 1047 00:48:17,960 --> 00:48:19,996 to be committed to body positivity 1048 00:48:19,997 --> 00:48:24,205 when, for enough money, you can buy your way out of it. 1049 00:48:29,082 --> 00:48:32,689 ♪ 1050 00:48:32,690 --> 00:48:34,626 Look at this. 1051 00:48:34,627 --> 00:48:38,266 This is basically two sizes down from what I was wearing. 1052 00:48:38,267 --> 00:48:41,405 I'm just getting ready 1053 00:48:41,406 --> 00:48:45,380 to go to a work-reunion event, 1054 00:48:45,381 --> 00:48:47,685 and I guess I'm kind of curious to see 1055 00:48:47,686 --> 00:48:50,390 if anyone will say anything. 1056 00:48:52,796 --> 00:48:56,703 Like, if it did come up, would I even tell the person? 1057 00:48:56,704 --> 00:48:58,440 I mean, the short answer is no. 1058 00:49:00,745 --> 00:49:03,684 In 2021, I got my first e-bike. 1059 00:49:03,685 --> 00:49:07,024 The idea was like, "Okay, if I get this e-bike, 1060 00:49:07,025 --> 00:49:08,761 I'm still putting out a lot of effort." 1061 00:49:08,762 --> 00:49:13,436 But, you know, when you're on an e-bike, 1062 00:49:13,437 --> 00:49:16,643 you can do more laps, 1063 00:49:16,644 --> 00:49:19,081 you can go farther, you can go faster. 1064 00:49:22,088 --> 00:49:23,657 And it's interesting with e-bikes 1065 00:49:23,658 --> 00:49:25,661 because it sort of mirrors 1066 00:49:25,662 --> 00:49:27,197 what's happening right now with GLP-1 meds 1067 00:49:27,198 --> 00:49:30,170 in that people who are anti-e-bike 1068 00:49:30,171 --> 00:49:32,709 are just like, "You're not earning it." 1069 00:49:32,710 --> 00:49:34,613 ♪ 1070 00:49:34,614 --> 00:49:37,552 "For $1,000, just get a meal service and go to the gym." 1071 00:49:37,553 --> 00:49:42,494 ♪ 1072 00:49:42,495 --> 00:49:44,164 McMillan Cottom: GLP-1s 1073 00:49:44,165 --> 00:49:48,674 do threaten our unexamined belief 1074 00:49:48,675 --> 00:49:52,381 that fat people deserve the way we treat them. 1075 00:49:52,382 --> 00:49:55,420 "We can't be sure. Who do we judge now? 1076 00:49:55,421 --> 00:49:57,659 Who-- How much should I judge them?" 1077 00:49:57,660 --> 00:50:00,463 That is a threat to my own social position. 1078 00:50:00,464 --> 00:50:02,835 Are we going to continue to pretend 1079 00:50:02,836 --> 00:50:04,673 like a lot of these conversations 1080 00:50:04,674 --> 00:50:07,645 aren't rooted in the gatekeeping of thin? 1081 00:50:07,646 --> 00:50:11,587 It's very clear that the people who have that mentality 1082 00:50:11,588 --> 00:50:15,427 don't have the experience that people like me have had. 1083 00:50:15,428 --> 00:50:17,197 Winfrey: I never dreamed 1084 00:50:17,198 --> 00:50:19,201 that we would be talking about medicines 1085 00:50:19,202 --> 00:50:22,374 that are providing hope for people like me, 1086 00:50:22,375 --> 00:50:25,080 who have struggled for years 1087 00:50:25,081 --> 00:50:27,484 with being overweight or with obesity. 1088 00:50:27,485 --> 00:50:30,290 As these drugs get more and more popular, 1089 00:50:30,291 --> 00:50:33,196 the cultural dialogue really goes to a fever pitch. 1090 00:50:33,197 --> 00:50:34,599 And of course, that's the point 1091 00:50:34,600 --> 00:50:37,471 that Oprah re-enters this conversation. 1092 00:50:37,472 --> 00:50:40,410 Hi, everybody. I wanted to do this special... 1093 00:50:40,411 --> 00:50:45,153 Blum: In March of 2024, Oprah does this entire special 1094 00:50:45,154 --> 00:50:47,692 that is devoted to weight-loss drugs 1095 00:50:47,693 --> 00:50:49,461 and how revolutionary they are. 1096 00:50:49,462 --> 00:50:52,535 In losing, you have now gained so much 1097 00:50:52,536 --> 00:50:53,771 in terms of your own health. 1098 00:50:53,772 --> 00:50:55,708 - Absolutely. - Yes. 1099 00:50:55,709 --> 00:50:58,446 And she says that she is taking a medication for weight loss. 1100 00:50:58,447 --> 00:51:00,685 She pretty pointedly doesn't say which one. 1101 00:51:00,686 --> 00:51:02,722 I use it as a tool. 1102 00:51:02,723 --> 00:51:04,826 Blum: It's really fascinating to have Oprah, 1103 00:51:04,827 --> 00:51:08,734 who has been for so long this sort of cultural avatar, 1104 00:51:08,735 --> 00:51:12,240 say that she is now to the point where she is in on this, too. 1105 00:51:12,241 --> 00:51:14,178 Winfrey: The two pharmaceutical companies 1106 00:51:14,179 --> 00:51:17,819 who are behind the meds, Ozempic and Wegovy, 1107 00:51:17,820 --> 00:51:20,691 Mounjaro and Zepbound, are here. 1108 00:51:20,692 --> 00:51:24,799 I think a lot of people felt almost betrayed. 1109 00:51:24,800 --> 00:51:26,503 It basically looked like 1110 00:51:26,504 --> 00:51:29,843 the manufacturers paid her to promote it. 1111 00:51:29,844 --> 00:51:31,780 Man: They come across as trying to be 1112 00:51:31,781 --> 00:51:35,353 some sort of neutral reporter, which is certainly not the case. 1113 00:51:35,354 --> 00:51:39,596 So, about two months later, Oprah does a whole new special, 1114 00:51:39,597 --> 00:51:42,501 and it is totally steeped in this language 1115 00:51:42,502 --> 00:51:43,804 of body positivity. 1116 00:51:43,805 --> 00:51:45,808 Winfrey: We have reached a pivotal moment 1117 00:51:45,809 --> 00:51:47,745 in the way we talk about 1118 00:51:47,746 --> 00:51:51,252 and the way we think about our bodies. 1119 00:51:51,253 --> 00:51:55,260 It was extremely surreal because I was watching Oprah 1120 00:51:55,261 --> 00:51:58,399 and this carousel of celebrities get up there 1121 00:51:58,400 --> 00:52:02,407 and use this kind of, like, "my body, my choice" rhetoric 1122 00:52:02,408 --> 00:52:03,944 around weight-loss drugs. 1123 00:52:03,945 --> 00:52:05,815 And our body is being up for debate, 1124 00:52:05,816 --> 00:52:07,752 our body is being weaponized, 1125 00:52:07,753 --> 00:52:12,729 our body is being used for legislation by bad actors, 1126 00:52:12,730 --> 00:52:15,433 and I've just had it. 1127 00:52:15,434 --> 00:52:17,605 And I was kind of looking around, watching 1128 00:52:17,606 --> 00:52:20,310 everyone in the room go through those mental gymnastics 1129 00:52:20,311 --> 00:52:22,782 of like, "Okay, it's empowering, 1130 00:52:22,783 --> 00:52:25,186 but the reason we're losing weight 1131 00:52:25,187 --> 00:52:28,292 is to fit into a body standard that's been foisted upon us, 1132 00:52:28,293 --> 00:52:30,463 but we're choosing to do it, so it's okay." 1133 00:52:30,464 --> 00:52:35,306 We want women's bodies to be off-topic. 1134 00:52:35,307 --> 00:52:37,277 It was just this total knot 1135 00:52:37,278 --> 00:52:39,783 that we were all trying to untangle. 1136 00:52:39,784 --> 00:52:41,686 And at a certain point, you just give up 1137 00:52:41,687 --> 00:52:44,224 because it's too interconnected. 1138 00:52:44,225 --> 00:52:45,895 Thanks, everybody. 1139 00:52:45,896 --> 00:52:49,501 Blum: I think the narrative around obesity and weight 1140 00:52:49,502 --> 00:52:52,775 stigma and shame gets even more complicated 1141 00:52:52,776 --> 00:52:54,813 when the drug companies get involved 1142 00:52:54,814 --> 00:52:56,850 and start putting out promos 1143 00:52:56,851 --> 00:53:00,691 that are basically staking out their own position 1144 00:53:00,692 --> 00:53:02,895 in a conversation about all the ways 1145 00:53:02,896 --> 00:53:06,603 in which our culture has demonized having a larger body. 1146 00:53:06,604 --> 00:53:08,005 Man: I was always told, 1147 00:53:08,006 --> 00:53:10,009 because I was overweight, I must be lazy. 1148 00:53:10,010 --> 00:53:11,913 Blum: These are forever drugs. 1149 00:53:11,914 --> 00:53:13,584 These are medications 1150 00:53:13,585 --> 00:53:15,988 that people need to stay on in perpetuity 1151 00:53:15,989 --> 00:53:17,792 if they want to keep the weight off. 1152 00:53:17,793 --> 00:53:21,332 And so these drug companies really stand to profit 1153 00:53:21,333 --> 00:53:24,438 from presenting themselves as the solution. 1154 00:53:24,439 --> 00:53:26,577 Man: We must stop fat-shaming. 1155 00:53:29,650 --> 00:53:33,356 Tovar: The proposition that a pharmaceutical company 1156 00:53:33,357 --> 00:53:35,828 can end weight discrimination 1157 00:53:35,829 --> 00:53:39,536 is ludicrous. 1158 00:53:39,537 --> 00:53:40,838 You're going to end weight stigma? 1159 00:53:40,839 --> 00:53:42,307 How? 1160 00:53:42,308 --> 00:53:43,877 By getting rid of every fat person 1161 00:53:43,878 --> 00:53:46,415 on the planet and the United States? 1162 00:53:46,416 --> 00:53:48,486 Okay, what does that actually look like? 1163 00:53:48,487 --> 00:53:50,423 It means that every person, 1164 00:53:50,424 --> 00:53:52,595 whether they want to take it or not, have to. 1165 00:53:52,596 --> 00:53:56,435 At the end of the day, what will happen is 1166 00:53:56,436 --> 00:53:58,574 that we won't have dealt with fat phobia. 1167 00:53:58,575 --> 00:54:01,780 We'll still be a society that has fat phobia. 1168 00:54:01,781 --> 00:54:03,584 We're not eradicating stigma. 1169 00:54:03,585 --> 00:54:05,955 We're eradicating the people who experience stigma. 1170 00:54:13,336 --> 00:54:15,808 ve been on my shots for six months now. 1171 00:54:15,809 --> 00:54:19,816 Throughout everything, I have lost 26 pounds. 1172 00:54:19,817 --> 00:54:21,820 Pretty close to 30. 1173 00:54:21,821 --> 00:54:22,788 I haven't done a weigh-in in a little bit, 1174 00:54:22,789 --> 00:54:24,826 so I could be there. 1175 00:54:27,566 --> 00:54:31,806 Luxmore: So, I've lost 64 pounds while being on the GLP-1 drugs. 1176 00:54:31,807 --> 00:54:35,681 It is... [Sighs] 1177 00:54:35,682 --> 00:54:37,785 20-some years of relief. 1178 00:54:41,125 --> 00:54:44,398 I've lost about 50 pounds since I started a GLP-1. 1179 00:54:44,399 --> 00:54:49,041 [ Exhaling sharply ] 1180 00:54:49,042 --> 00:54:51,345 This is the first time in my life 1181 00:54:51,346 --> 00:54:53,550 that I've ever been on a weight-loss journey 1182 00:54:53,551 --> 00:54:55,955 and my legs have actually transformed. 1183 00:54:55,956 --> 00:54:58,426 And I don't think I realized how much 1184 00:54:58,427 --> 00:55:01,533 I was living in pain in my legs before, 1185 00:55:01,534 --> 00:55:02,935 because I just tolerated it. 1186 00:55:02,936 --> 00:55:04,739 Right up there? Yeah? 1187 00:55:04,740 --> 00:55:08,412 Blum: GLP-1s are extremely exciting. 1188 00:55:08,413 --> 00:55:09,983 They were revolutionary. 1189 00:55:09,984 --> 00:55:11,519 I've never heard the word "miracle" 1190 00:55:11,520 --> 00:55:13,857 come up so many times in my reporting. 1191 00:55:13,858 --> 00:55:16,061 It's really easy to get swept up in the hype 1192 00:55:16,062 --> 00:55:19,501 around these medications. 1193 00:55:19,502 --> 00:55:21,438 Arrellin: It's already helped all the PCOS stuff. 1194 00:55:21,439 --> 00:55:23,543 Like a normal girl now, honestly. 1195 00:55:23,544 --> 00:55:27,450 I'm in a size 9 in my jeans, 1196 00:55:27,451 --> 00:55:29,087 so that's pretty nice. 1197 00:55:29,088 --> 00:55:32,828 Luxmore: The forum I'm on a lot on Reddit, 1198 00:55:32,829 --> 00:55:36,135 they talk about NSV-- non-scale victory. 1199 00:55:36,136 --> 00:55:39,509 There's, like, an NSV, like, every day. 1200 00:55:39,510 --> 00:55:40,644 These are much better. 1201 00:55:40,645 --> 00:55:42,447 So it gives a lot of hope now. 1202 00:55:42,448 --> 00:55:43,884 I'm not mad about that. 1203 00:55:43,885 --> 00:55:47,525 So, this is what we call a non-scale victory. 1204 00:55:47,526 --> 00:55:49,061 [ Sighs ] 1205 00:55:49,062 --> 00:55:51,833 This was supposed to be the easy interview. 1206 00:55:51,834 --> 00:55:54,706 [ Sighs ] 1207 00:55:54,707 --> 00:55:56,743 ♪ 1208 00:55:56,744 --> 00:55:58,012 Luxmore: The goal, really, I think, 1209 00:55:58,013 --> 00:55:59,916 is to have more social connections. 1210 00:55:59,917 --> 00:56:03,757 So maybe I can go on dates now, and I could convince myself 1211 00:56:03,758 --> 00:56:05,493 that my size isn't really a factor. 1212 00:56:05,494 --> 00:56:07,732 ♪ 1213 00:56:07,733 --> 00:56:10,003 I think I'm ready to start trying that again. 1214 00:56:10,004 --> 00:56:11,573 [ Camera timer beeping ] 1215 00:56:11,574 --> 00:56:13,409 One of my dream scenarios would be, like, 1216 00:56:13,410 --> 00:56:15,113 I go on a date and my date would say, 1217 00:56:15,114 --> 00:56:17,652 "By the way, I'm taking Ozempic." 1218 00:56:17,653 --> 00:56:20,625 Like, if I heard that, I'd just be like, "I love you." 1219 00:56:23,731 --> 00:56:27,037 Sanchez: I think, with any type of medical treatment, 1220 00:56:27,038 --> 00:56:28,940 there's risk involved, so I think 1221 00:56:28,941 --> 00:56:30,811 it's up to your choice 1222 00:56:30,812 --> 00:56:33,149 what level of risk you're willing to take. 1223 00:56:33,150 --> 00:56:36,756 I finally got approved for Zepbound 1224 00:56:36,757 --> 00:56:39,762 because my insurance company now covers it, 1225 00:56:39,763 --> 00:56:42,033 and my copay is $25 a month. 1226 00:56:42,034 --> 00:56:44,772 My goal is to just have Zepbound 1227 00:56:44,773 --> 00:56:47,110 only for financial reasons. 1228 00:56:47,111 --> 00:56:49,615 However, that could change overnight, 1229 00:56:49,616 --> 00:56:52,454 so I'll still have a backup plan-- 1230 00:56:52,455 --> 00:56:54,659 a plan B with my peptides. 1231 00:56:54,660 --> 00:56:57,631 Just in case. [ Chuckles ] 1232 00:56:57,632 --> 00:57:01,573 I know so many people are so mad at me for saying this. 1233 00:57:01,574 --> 00:57:03,677 GLP-1s are a diet. 1234 00:57:03,678 --> 00:57:07,585 At the end of the day, 1235 00:57:07,586 --> 00:57:09,922 diets are when you restrict food 1236 00:57:09,923 --> 00:57:12,828 in order to change your body size. 1237 00:57:12,829 --> 00:57:15,667 That is what a GLP-1 does. 1238 00:57:15,668 --> 00:57:17,938 It does it in kind of an elaborate way. 1239 00:57:17,939 --> 00:57:20,476 It does it in kind of, like, a more medicalized way, 1240 00:57:20,477 --> 00:57:24,519 but, fundamentally, it is a food-restriction program. 1241 00:57:24,520 --> 00:57:28,492 Luxmore: So, right now, I weigh 259 pounds. 1242 00:57:28,493 --> 00:57:32,000 At my lowest weight, without GLP-1, 1243 00:57:32,001 --> 00:57:34,038 I had gotten to, like, 261. 1244 00:57:35,742 --> 00:57:39,047 And I'd done that through diet and exercise. 1245 00:57:39,048 --> 00:57:41,753 At that point, I did feel really confident. 1246 00:57:41,754 --> 00:57:45,026 But this time around, I'm not really having that. 1247 00:57:45,027 --> 00:57:47,732 That feeling is not explicitly tied to your size. 1248 00:57:47,733 --> 00:57:49,167 It's tied to other things. 1249 00:57:49,168 --> 00:57:51,105 And I haven't nailed down what that is. 1250 00:57:51,106 --> 00:57:53,543 Today I slept all day because I wasn't feeling good at all. 1251 00:57:53,544 --> 00:57:55,581 Very, very difficult. 1252 00:57:55,582 --> 00:57:57,083 I don't like how sick it makes me feel. 1253 00:57:57,084 --> 00:57:58,687 I'm very happy for what it's doing to me, 1254 00:57:58,688 --> 00:58:00,557 and I'm very happy that I got to be 1255 00:58:00,558 --> 00:58:02,093 a part of the study that I'm in. 1256 00:58:02,094 --> 00:58:04,164 That was me when I-- on my 13th birthday. 1257 00:58:04,165 --> 00:58:07,270 I was a lot bigger then. I'm very happy I've lost weight. 1258 00:58:07,271 --> 00:58:09,575 I just don't like feeling sick. 1259 00:58:09,576 --> 00:58:14,552 Tovar: Chronic nausea, gastroparesis, hair loss, 1260 00:58:14,553 --> 00:58:16,956 the idea that you might have to pay out-of-pocket 1261 00:58:16,957 --> 00:58:20,597 $20,000 a year for the rest of your life. 1262 00:58:20,598 --> 00:58:24,337 Why aren't any of those things worthy of headlines? 1263 00:58:24,338 --> 00:58:27,277 Why is the only thing that's worthy of headlines 1264 00:58:27,278 --> 00:58:30,216 that this is a quote, unquote, miracle drug? 1265 00:58:32,755 --> 00:58:36,061 Luxmore: My expectation is that I'm going to be taking GLP-1s 1266 00:58:36,062 --> 00:58:38,299 indefinitely, which is expensive. 1267 00:58:38,300 --> 00:58:41,271 I'm very fortunate that I can afford-- 1268 00:58:41,272 --> 00:58:44,311 If I had to pay full price, I can still afford it. 1269 00:58:44,312 --> 00:58:47,117 Arrellin: After the trial ends, my doctor said 1270 00:58:47,118 --> 00:58:51,993 that I won't be on it anymore unless something happens 1271 00:58:51,994 --> 00:58:54,665 and it becomes, like, an actual PCOS med. 1272 00:58:54,666 --> 00:58:57,705 I don't want to end up where I was in the beginning. 1273 00:58:57,706 --> 00:58:59,341 McMillan Cottom: As they stand now, 1274 00:58:59,342 --> 00:59:02,046 GLP-1 drugs for weight loss 1275 00:59:02,047 --> 00:59:04,619 are for people who are at risk 1276 00:59:04,620 --> 00:59:08,660 for losing social status and money 1277 00:59:08,661 --> 00:59:10,831 if they aren't thin, 1278 00:59:10,832 --> 00:59:14,605 and for people who can afford to take that risk. 1279 00:59:14,606 --> 00:59:19,147 As a country, we need to decide if we are okay with that. 1280 00:59:19,148 --> 00:59:22,988 I'm happy to, like, confidently wear this. 1281 00:59:22,989 --> 00:59:25,159 Harrison: To really improve people's well-being, 1282 00:59:25,160 --> 00:59:27,030 we need to focus on ending the cultural obsession 1283 00:59:27,031 --> 00:59:29,000 with dieting and body image... 1284 00:59:29,001 --> 00:59:32,173 Woman: There's been a more than 930% increase 1285 00:59:32,174 --> 00:59:35,079 in patients getting prescription semaglutide. 1286 00:59:35,080 --> 00:59:38,385 Harrison: ...helping people develop resilience to that. 1287 00:59:38,386 --> 00:59:41,626 And it looks good, and it makes me feel good. 1288 00:59:41,627 --> 00:59:43,663 Gay: If we could just let people live 1289 00:59:43,664 --> 00:59:45,266 and be who they are, 1290 00:59:45,267 --> 00:59:47,771 and try and address some of the stigmas around fatness, 1291 00:59:47,772 --> 00:59:50,076 maybe you would see fewer fat people. 1292 00:59:50,077 --> 00:59:52,715 I don't know. We could try it. 1293 00:59:52,716 --> 00:59:56,321 But we won't. 1294 00:59:56,322 --> 01:00:07,778 ♪ 1295 01:00:11,219 --> 01:00:45,053 ♪